INCENP — the targeting and activating subunit of Aurora B kinase— has several key mitotic functions. Now, INCENP emerges as a nodal point of the network of kinases that regulate mitotic events. Phosphorylation of INCENP by CDK1 is required for the kinetochore localization of Plk1 kinase, and this in turn is necessary for a timely metaphase–anaphase transition.
- Mar Carmena
- William C. Earnshaw
