Nature Search

A framework for evaluating the chemical knowledge and reasoning abilities of large language models against the expertise of chemists

Large language models are increasingly used for diverse tasks, yet we have limited insight into their understanding of chemistry. Now ChemBench—a benchmarking framework containing more than 2,700 question–answer pairs—has been developed to assess their chemical knowledge and reasoning, revealing that the best models surpass human chemists on average but struggle with some basic tasks.

Adrian Mirza
Nawaf Alampara
Kevin Maik Jablonka
ResearchOpen Access20 May 2025
Nature Chemistry

Volume: 17, P: 1027-1034
GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
ResearchOpen Access17 May 2023
Nature

Volume: 617, P: 764-768
Author Correction: Cancer cell metabolism and antitumour immunity

Mara De Martino
Jeffrey C. Rathmell
Claire Vanpouille-Box
Amendments and Corrections28 May 2024
Nature Reviews Immunology

Volume: 24, P: 537
AMPA receptor GluA2 subunit defects are a cause of neurodevelopmental disorders

Genetic variants in ionotropic glutamate receptors have been implicated in neurodevelopmental disorders. Here, the authors report heterozygous de novo mutations in the GRIA2 gene in 28 individuals with intellectual disability and neurodevelopmental abnormalities associated with reduced Ca²⁺ transport and AMPAR currents.”

Vincenzo Salpietro
Christine L. Dixon
Henry Houlden
ResearchOpen Access12 Jul 2019
Nature Communications

Volume: 10, P: 1-16
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Age differentially impacts adaptive immune responses induced by adenoviral versus mRNA vaccines against COVID-19

Age-related immune dysfunction can compromise immune responses to infection and vaccine efficacy. Across two cohorts, Dallan et al. demonstrate that protective immunity against severe acute respiratory syndrome coronavirus is optimally maintained in older adults after primary adenoviral immunization (ChAdOx1-S) and subsequent mRNA vaccine boosting (BNT162b2 or mRNA-1273).

Beatrice Dallan
Davide Proietto
Francesco Nicoli
Research25 Jun 2024
Nature Aging

Volume: 4, P: 1121-1136
Rare coding variation provides insight into the genetic architecture and phenotypic context of autism

Analysis of rare protein-truncating, damaging missense and copy number variants from exome sequencing of 63,237 individuals identifies 72 genes associated with autism spectrum disorder.

Jack M. Fu
F. Kyle Satterstrom
Michael E. Talkowski
Research18 Aug 2022
Nature Genetics

Volume: 54, P: 1320-1331
Altered structural brain asymmetry in autism spectrum disorder in a study of 54 datasets

Changes in brain structure asymmetry have been reported in autism spectrum disorder. Here the authors investigate this issue using a large-scale sample consisting of 54 data sets.

Merel C. Postema
Daan van Rooij
Clyde Francks
ResearchOpen Access31 Oct 2019
Nature Communications

Volume: 10, P: 1-12
The CIP2A–TOPBP1 axis safeguards chromosome stability and is a synthetic lethal target for BRCA-mutated cancer

Durocher and colleagues identify CIP2A through synthetic lethal CRISPR screens as a key regulator of adaptive feedback mechanisms controlling chromosomal stability arising from accumulated DNA lesions in BRCA-mutated tumor cells.

Salomé Adam
Silvia Emma Rossi
Daniel Durocher
Research11 Nov 2021
Nature Cancer

Volume: 2, P: 1357-1371
Author Correction: GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
Amendments and CorrectionsOpen Access11 Jul 2023
Nature

Volume: 619, P: E61
Author Correction: Altered structural brain asymmetry in autism spectrum disorder in a study of 54 datasets

Merel C. Postema
Daan van Rooij
Clyde Francks
Amendments and CorrectionsOpen Access08 Dec 2021
Nature Communications

Volume: 12, P: 1
Shaping current European mitochondrial haplogroup frequency in response to infection: the case of SARS-CoV-2 severity

Genetic and Structural analysis of COVID patients cohort reveals a correlation between mitochondrial haplogroup and SARS-CoV-2 severity.

José Luis Cabrera-Alarcon
Raquel Cruz
José Antonio Enriquez
ResearchOpen Access09 Jan 2025
Communications Biology

Volume: 8, P: 1-12
Cancer cell metabolism and antitumour immunity

This Review discusses the mechanisms by which common alterations of cancer cell metabolism interfere with immune functions to promote immunoevasion and tumour progression, and avenues to target such alterations for therapeutic purposes.

Mara De Martino
Jeffrey C. Rathmell
Claire Vanpouille-Box
Reviews22 Apr 2024
Nature Reviews Immunology

Volume: 24, P: 654-669
Global Roadkill Data: a dataset on terrestrial vertebrate mortality caused by collision with vehicles

Clara Grilo
Tomé Neves
Eric Guinard
ResearchOpen Access31 Mar 2025
Scientific Data

Volume: 12, P: 1-14
Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality.

Luis A. Pérez-Jurado
Alejandro Cáceres
Juan R. González
ResearchOpen Access19 Feb 2024
Communications Biology

Volume: 7, P: 1-14
Canonical ErbB-2 isoform and ErbB-2 variant c located in the nucleus drive triple negative breast cancer growth

María F. Chervo
Rosalía I. Cordo Russo
Patricia V. Elizalde
Research25 Aug 2020
Oncogene

Volume: 39, P: 6245-6262
Determinants of SARS-CoV-2 infection in Italian healthcare workers: a multicenter study

Paolo Boffetta
Francesco Violante
Attilia Gullino
ResearchOpen Access11 Mar 2021
Scientific Reports

Volume: 11, P: 1-8
Polygenic risk score-based phenome-wide association study identifies novel associations for Tourette syndrome

Pritesh Jain
Tyne Miller-Fleming
Peristera Paschou
ResearchOpen Access23 Feb 2023
Translational Psychiatry

Volume: 13, P: 1-10
Halting ErbB-2 isoforms retrograde transport to the nucleus as a new theragnostic approach for triple-negative breast cancer

Santiago Madera
Franco Izzo
Rosalía I. Cordo Russo
ResearchOpen Access09 May 2022
Cell Death & Disease

Volume: 13, P: 1-14
Correction: Halting ErbB-2 isoforms retrograde transport to the nucleus as a new theragnostic approach for triple-negative breast cancer

Santiago Madera
Franco Izzo
Rosalía I. Cordo Russo
Amendments and CorrectionsOpen Access15 Dec 2023
Cell Death & Disease

Volume: 14, P: 1-3

Search

A framework for evaluating the chemical knowledge and reasoning abilities of large language models against the expertise of chemists

GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Author Correction: Cancer cell metabolism and antitumour immunity

AMPA receptor GluA2 subunit defects are a cause of neurodevelopmental disorders

A second update on mapping the human genetic architecture of COVID-19

Age differentially impacts adaptive immune responses induced by adenoviral versus mRNA vaccines against COVID-19

Rare coding variation provides insight into the genetic architecture and phenotypic context of autism

Altered structural brain asymmetry in autism spectrum disorder in a study of 54 datasets

The CIP2A–TOPBP1 axis safeguards chromosome stability and is a synthetic lethal target for BRCA-mutated cancer

Author Correction: GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Author Correction: Altered structural brain asymmetry in autism spectrum disorder in a study of 54 datasets

Shaping current European mitochondrial haplogroup frequency in response to infection: the case of SARS-CoV-2 severity

Cancer cell metabolism and antitumour immunity

Global Roadkill Data: a dataset on terrestrial vertebrate mortality caused by collision with vehicles

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

Canonical ErbB-2 isoform and ErbB-2 variant c located in the nucleus drive triple negative breast cancer growth

Determinants of SARS-CoV-2 infection in Italian healthcare workers: a multicenter study

Polygenic risk score-based phenome-wide association study identifies novel associations for Tourette syndrome

Halting ErbB-2 isoforms retrograde transport to the nucleus as a new theragnostic approach for triple-negative breast cancer

Correction: Halting ErbB-2 isoforms retrograde transport to the nucleus as a new theragnostic approach for triple-negative breast cancer

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