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Nature Cell Biology (1)

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LIN28 phosphorylation by MAPK/ERK couples signalling to the post-transcriptional control of pluripotency

Daley and colleagues report that MAPK signalling controls pluripotency in embryonic stem cells and during somatic cell reprogramming by enhancing the stability and effects of LIN28 on direct mRNA targets through its phosphorylation by ERK.

Kaloyan M. Tsanov
Daniel S. Pearson
George Q. Daley
Research19 Dec 2016
Nature Cell Biology

Volume: 19, P: 60-67

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LIN28 phosphorylation by MAPK/ERK couples signalling to the post-transcriptional control of pluripotency

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