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Showing 1–4 of 4 results
Advanced filters: Author: Marc Hennequart Clear advanced filters

  • Cancer cells in culture are often grown in media conditions containing unphysiological metabolite levels. Here, the authors grow cells under physiological metabolite levels to further understand the reliance of cells on serine and find that when grown under these conditions the cells are less sensitive to serine withdrawal.

    • Marc Hennequart
    • Christiaan F. Labuschagne
    • Karen H. Vousden
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-10

  • Dietary serine and glycine starvation has emerged as a potential therapy for cancer. Here, the authors show that inhibition of PHGDH, which mediates the first step in the serine synthesis pathway, improves the therapeutic efficacy of serine depletion diet in mouse xenograft models.

    • Mylène Tajan
    • Marc Hennequart
    • Karen H. Vousden
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-16

  • Vousden and colleagues discuss the multifactorial role of mitochondrial folate metabolism in cancer and metastasis and reflect on potential therapeutic opportunities.

    • Younghwan Lee
    • Karen H. Vousden
    • Marc Hennequart
    Reviews
    Nature Cancer
    Volume: 5, P: 701-715