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Showing 1–2 of 2 results
Advanced filters: Author: Marc Revol Clear advanced filters

  • HIV-1 eradication is hindered by viral persistence in different cell reservoirs, including circulatory CD4+ T-cells and tissue-resident macrophages. Here, by analyzing male genital mucosa from cART-suppressed HIV1-infected individuals, Real et al. show that M4 macrophages represent the major macrophage HIV-1 reservoir in this tissue. These macrophages have an inflammatory IL1R+S100A8+MMP7+M4-phenotype, and contain transcriptionally active HIV-1, which reactivate infectious virus production from viral latency in response to autocrine/paracrine S100A8-mediated glycolysis.

    • Fernando Real
    • Aiwei Zhu
    • Morgane Bomsel
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-16

  • Suppressive combination antiretroviral therapy fails to eradicate HIV-1 latent reservoirs in poorly characterized cell compartments. Here, urethral macrophages, but not urethral T cells, are shown to contain integrated HIV-1 DNA and to be able to release infectious HIV-1 following reactivation with lipopolysaccharide.

    • Yonatan Ganor
    • Fernando Real
    • Morgane Bomsel
    Research
    Nature Microbiology
    Volume: 4, P: 633-644