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Showing 1–19 of 19 results
Advanced filters: Author: Marc Y Donath Clear advanced filters

  • The cytokine IL-1β has well-established harmful effects on pancreatic islet function. Donath and colleagues identify an acute wave of postprandial IL-1β release and show that this unexpectedly has a positive effect on insulin secretion and the maintenance of normal metabolic function.

    • Erez Dror
    • Elise Dalmas
    • Marc Y Donath
    Research
    Nature Immunology
    Volume: 18, P: 283-292

  • Although the mechanisms of β-cell failure in type 2 diabetes mellitus remain debated, islet inflammation is implicated and the cytokine interleukin-1β has emerged as a master regulator of this process. The potential role of anakinra—a recombinant human IL-1-receptor antagonist—in the treatment of type 2 diabetes mellitus is discussed.

    • Marc Y Donath
    • Thomas Mandrup-Poulsen
    Reviews
    Nature Clinical Practice Endocrinology & Metabolism
    Volume: 4, P: 240-241

  • The consequences of postprandial IL-1β surges in white adipose tissue are unknown. Here the authors show IL-1β regulates WAT remodelling by promoting adipogenesis and energy storage, which is blocked by chronic elevation of this cytokine (as in obesity).

    • Kaisa Hofwimmer
    • Joyce de Paula Souza
    • Jurga Laurencikiene
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-18

  • Defective insulin secretion is observed early in the development of diabetes. Here the authors report that β cell-specific deficiency of the insulin prohormone convertase 1/3 (PC1/3) leads not only to hyperglycemia, but also to hyperphagic obesity in mice.

    • Daniel T. Meier
    • Leila Rachid
    • Marc Y. Donath
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-13

  • Increasing evidence points to a role for the immune system in the regulation of metabolism. Two new studies in mice indicate treatment with interleukin-22 restores mucosal immunity in diabetes and alleviates metabolic disease, resulting in improved glycemic control.

    • Elise Dalmas
    • Marc Y Donath
    News & Views
    Nature Medicine
    Volume: 20, P: 1379-1381

  • Obesity induces metabolic stress and is associated with inflammation. A cellular pathway now links SIRT2, a deacetylase involved in metabolic processes, to cytoskeleton remodelling and activation of the NLRP3 inflammasome.

    • Marc Y Donath
    News & Views
    Nature Immunology
    Volume: 14, P: 421-422

  • Inflammation is now appreciated to have an important role in the pathogenesis of type 2 diabetes and associated complications. Donath describes the underlying mechanisms and discusses the rationale for the use of anti-inflammatory agents — such as those that have been developed for rheumatoid arthritis and other diseases driven by inflammatory processes — in patients with diabetes.

    • Marc Y. Donath
    Reviews
    Nature Reviews Drug Discovery
    Volume: 13, P: 465-476

  • The authors consider the inflammatory basis of type 1 and type 2 diabetes. In particular, they focus on the role of IL-1β in both diseases and discuss the feasibility of targeting innate immune mechanisms in the clinic.

    • Marc Y. Donath
    • Charles A. Dinarello
    • Thomas Mandrup-Poulsen
    Reviews
    Nature Reviews Immunology
    Volume: 19, P: 734-746

  • Findeisen et al. have engineered IC7Fc, a cytokine for the treatment of type 2 diabetes, that selectively activates beneficial metabolic pathways systemically and in metabolic tissues without promoting an inflammatory response.

    • Marc Y. Donath
    News & Views
    Nature Metabolism
    Volume: 1, P: 933-934

  • β-cell dysfunction in type 2 diabetes is associated with pathological aggregates of IAPP that accumulate in pancreatic islets. Here, the authors describe a novel antibody cloned from healthy elderly donors that selectively targets IAPP oligomers and protects from IAPP toxicity.

    • Fabian Wirth
    • Fabrice D. Heitz
    • Jan Grimm
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-15

  • Helga Ellingsgaard et al. show that secretion of interleukin-6 by muscle in response to exercise, or injection of recombinant protein, increases the expression of the incretin GLP-1 by both intestinal cells and by pancreatic alpha cells, thus potentiating insulin release and improving glycemic control. These results identify a new endocrine loop linking energy demands to homeostatic control while also suggesting further targets for type 2 diabetes therapy.

    • Helga Ellingsgaard
    • Irina Hauselmann
    • Marc Y Donath
    Research
    Nature Medicine
    Volume: 17, P: 1481-1489

  • The cellular stresses that are proposed to underlie impaired insulin secretion and sensitivity in type 2 diabetes can also trigger inflammation. Here, the authors explain how inflammatory mechanisms are involved in the pathogenesis of type 2 diabetes and how this knowledge is directing immunomodulatory strategies for treating the disease.

    • Marc Y. Donath
    • Steven E. Shoelson
    Reviews
    Nature Reviews Immunology
    Volume: 11, P: 98-107

  • Maria Teschler-Nicola et al. use ancient DNA sequencing to report the earliest known case of human monozygotic twins found in a previously discovered Upper Palaeolithic burial site. Using bioanthropological and archaeological techniques, they also find that the twins were full-term newborns and that ancient mortuary behavior included re-opening of grave sites to bury related individuals together.

    • Maria Teschler-Nicola
    • Daniel Fernandes
    • Ron Pinhasi
    ResearchOpen Access
    Communications Biology
    Volume: 3, P: 1-11

  • Netea and colleagues provide a general guide to the cellular and humoral contributors to inflammation as well as the pathways that characterize inflammation in specific organs and tissues.

    • Mihai G Netea
    • Frances Balkwill
    • Charles A Dinarello
    Comments & Opinion
    Nature Immunology
    Volume: 18, P: 826-831