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Understanding the molecular diversity of synapses

The set of proteins present at synapses determines their heterogeneous functions and properties. In this Review, van Oostrum and Schuman describe the molecular mechanisms that contribute to the diversity of the synaptic proteome and consider how this molecular complexity can be captured by approaches for synapse classification.

Marc van Oostrum
Erin M. Schuman
Reviews05 Dec 2024
Nature Reviews Neuroscience

Volume: 26, P: 65-81
Classification of mouse B cell types using surfaceome proteotype maps

Analysis of the cell surface proteome (surfaceome) is essential for cell classification but is technically challenging. Here the authors miniaturize and automate the Cell Surface Capture method to increase sensitivity, reproducibility and throughput, and use it to create population-specific surfaceome maps of developing mouse B cells.

Marc van Oostrum
Maik Müller
Bernd Wollscheid
ResearchOpen Access16 Dec 2019
Nature Communications

Volume: 10, P: 1-9
Author Correction: Surfaceome dynamics reveal proteostasis-independent reorganization of neuronal surface proteins during development and synaptic plasticity

Marc van Oostrum
Benjamin Campbell
Bernd Wollscheid
Amendments and CorrectionsOpen Access06 Nov 2020
Nature Communications

Volume: 11, P: 1
Proteogenetic drug response profiling elucidates targetable vulnerabilities of myelofibrosis

Myelofibrosis is a form of myeloproliferative neoplasm with few treatment options available. Here, the authors profiled drug responses and proteomics ex vivo and identify molecularly-guided treatment strategies, including HDAC and BET inhibitors for CALR mutant myelofibrosis patients.

Mattheus H. E. Wildschut
Julien Mena
Berend Snijder
ResearchOpen Access12 Oct 2023
Nature Communications

Volume: 14, P: 1-19
A tissue-specific atlas of protein–protein associations enables prioritization of candidate disease genes

Protein–protein interactions specific to 11 individual tissues are presented in a comprehensive resource.

Diederik S. Laman Trip
Marc van Oostrum
Pedro Beltrao
ResearchOpen Access02 May 2025
Nature Biotechnology

P: 1-14
Surfaceome dynamics reveal proteostasis-independent reorganization of neuronal surface proteins during development and synaptic plasticity

Cell surface proteins contribute to neuronal development and activity-dependent synaptic plasticity. Here, the authors perform a time-resolved surfaceome analysis of developing primary neurons and in response to homeostatic synaptic scaling and chemical long-term potentiation (cLTP), revealing surface proteome remodeling largely independent of global proteostasis.

Marc van Oostrum
Benjamin Campbell
Bernd Wollscheid
ResearchOpen Access05 Oct 2020
Nature Communications

Volume: 11, P: 1-16
Light-mediated discovery of surfaceome nanoscale organization and intercellular receptor interaction networks

The spatial organization of cell surface receptors is critical for cell signaling and drug action. Here, the authors develop an optoproteomic method for mapping surface protein interactions, revealing cellular responses to antibodies, drugs and viral particles as well as immunosynapse signaling events.

Maik Müller
Fabienne Gräbnitz
Bernd Wollscheid
ResearchOpen Access02 Dec 2021
Nature Communications

Volume: 12, P: 1-17

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Understanding the molecular diversity of synapses

Classification of mouse B cell types using surfaceome proteotype maps

Author Correction: Surfaceome dynamics reveal proteostasis-independent reorganization of neuronal surface proteins during development and synaptic plasticity

Proteogenetic drug response profiling elucidates targetable vulnerabilities of myelofibrosis

A tissue-specific atlas of protein–protein associations enables prioritization of candidate disease genes

Surfaceome dynamics reveal proteostasis-independent reorganization of neuronal surface proteins during development and synaptic plasticity

Light-mediated discovery of surfaceome nanoscale organization and intercellular receptor interaction networks

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