Nature Search

Synthetic mycobacterial molecular patterns partially complete Freund’s adjuvant

Jean-Yves Dubé
Fiona McIntosh
Marcel A. Behr
ResearchOpen Access03 Apr 2020
Scientific Reports

Volume: 10, P: 1-14
Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17–producing T cells

Marcel Batten
Ji Li
Nico Ghilardi
Research13 Aug 2006
Nature Immunology

Volume: 7, P: 929-936
Speos: an ensemble graph representation learning framework to predict core gene candidates for complex diseases

Understanding phenotype-genotype relationships is a grand challenge of current biological research. Here, the authors use graph representation learning to identify human genes which display key characteristics of core genes for five complex diseases.

Florin Ratajczak
Mitchell Joblin
Matthias Heinig
ResearchOpen Access08 Nov 2023
Nature Communications

Volume: 14, P: 1-18
A third vaccination with a single T cell epitope confers protection in a murine model of SARS-CoV-2 infection

Vaccination regimens and the number of doses required for optimal immunity and protection are critical factors in the translation of vaccines. Here the authors show administration of a three dose protocol of a single T cell epitope to the SARS-CoV-2 spike protein induces a robust CD8⁺ T cell response and confers protection in a lethal murine challenge model of infection.

Iris N. Pardieck
Tetje C. van der Sluis
Ramon Arens
ResearchOpen Access08 Jul 2022
Nature Communications

Volume: 13, P: 1-11
Protective effect of TCR-mediated MAIT cell activation during experimental autoimmune encephalomyelitis

Mucosal-associated invariant T (MAIT) cells mediate protection from pathogens, but their role in autoimmunity is unclear. Here the authors show that, in a mouse experimental autoimmune encephalomyelitis model, MAIT cells accumulate in the inflamed central nervous system and serve protective functions when activated via their T cell receptor.

Mark Walkenhorst
Jana K. Sonner
Anne Willing
ResearchOpen Access28 Oct 2024
Nature Communications

Volume: 15, P: 1-16
Inhibition of neuronal FLT3 receptor tyrosine kinase alleviates peripheral neuropathic pain in mice

Sensitisation of dorsal root ganglia neurons contributes to neuropathic pain. Here the authors demonstrate the cytokine FL contributes to sensitisation of DRGs via its receptor FLT3 expressed on neurons, and identify a novel FLT3 inhibitor that attenuates neuropathic pain in mice.

Cyril Rivat
Chamroeun Sar
Jean Valmier
ResearchOpen Access12 Mar 2018
Nature Communications

Volume: 9, P: 1-13
A network of trans-cortical capillaries as mainstay for blood circulation in long bones

Bone marrow-derived cells can rapidly enter the systemic circulation, but how this is achieved is unclear. Grüneboom et al. identify tiny capillaries, termed trans-cortical vessels (TCVs), that connect the bone marrow cavity to the systemic vasculature, and show that the majority of blood in long bones passes through TCVs.

Anika Grüneboom
Ibrahim Hawwari
Matthias Gunzer
Research21 Jan 2019
Nature Metabolism

Volume: 1, P: 236-250
High-throughput single-cell activity-based screening and sequencing of antibodies using droplet microfluidics

Millions of primary IgG-secreting cells from mouse and human are characterized for activity and antibody sequence at the single-cell level.

Annabelle Gérard
Adam Woolfe
Colin Brenan
Research30 Mar 2020
Nature Biotechnology

Volume: 38, P: 715-721
Selective cytotoxic T-lymphocyte targeting of tumor immune escape variants

Thorbald van Hall
Elisabeth Z Wolpert
Rienk Offringa
Research19 Mar 2006
Nature Medicine

Volume: 12, P: 417-424
A Cre-inducible diphtheria toxin receptor mediates cell lineage ablation after toxin administration

Thorsten Buch
Frank L Heppner
Ari Waisman
Research20 May 2005
Nature Methods

Volume: 2, P: 419-426
Bassoon proteinopathy drives neurodegeneration in multiple sclerosis

The authors report that the presynaptic protein bassoon forms toxic aggregates in neuronal somata in multiple sclerosis. Stimulation of proteasomal activity reduces bassoon aggregates, neuroaxonal loss and disability during CNS inflammation.

Benjamin Schattling
Jan Broder Engler
Manuel A. Friese
Research22 Apr 2019
Nature Neuroscience

Volume: 22, P: 887-896
FANCI is a second monoubiquitinated member of the Fanconi anemia pathway

Ashley E Sims
Elizabeth Spiteri
Tony T Huang
Research25 Apr 2007
Nature Structural & Molecular Biology

Volume: 14, P: 564-567
Biallelic mutations in PALB2 cause Fanconi anemia subtype FA-N and predispose to childhood cancer

Sarah Reid
Detlev Schindler
Nazneen Rahman
Research31 Dec 2006
Nature Genetics

Volume: 39, P: 162-164
A Nonpeptide Oxytocin Receptor Agonist for a Durable Relief of Inflammatory Pain

Louis Hilfiger
Qian Zhao
Alexandre Charlet
ResearchOpen Access20 Feb 2020
Scientific Reports

Volume: 10, P: 1-10
Phylogeography of the second plague pandemic revealed through analysis of historical Yersinia pestis genomes

The second plague pandemic, caused by Yersinia pestis, started in the 14th century and recurred in Europe until the 18th century. Here, the authors reconstruct ancient Y. pestis genomes from human remains spanning this period, shedding light into the phylogeography and population structure of the European strains.

Maria A. Spyrou
Marcel Keller
Johannes Krause
ResearchOpen Access02 Oct 2019
Nature Communications

Volume: 10, P: 1-13
Antigen discovery unveils resident memory and migratory cell roles in antifungal resistance

Hannah E. Dobson
Lucas Dos Santos Dias
Marcel Wüthrich
Research03 Jan 2020
Mucosal Immunology

Volume: 13, P: 518-529
S100B immunization triggers NFκB and complement activation in an autoimmune glaucoma model

Sabrina Reinehr
Jacqueline Reinhard
Stephanie C. Joachim
ResearchOpen Access29 Jun 2018
Scientific Reports

Volume: 8, P: 1-12
Prognosis and quality of life in patients with locally advanced rectal cancer after abdominoperineal resection in the CAO/ARO/AIO-04 randomized phase 3 trial

Jochen Gaedcke
Malte Sahrhage
H. Leber
ResearchOpen Access13 Feb 2025
Scientific Reports

Volume: 15, P: 1-12
Mutation of the RAD51C gene in a Fanconi anemia–like disorder

Christopher Mathew and colleagues report a homozygous germline mutation of RAD51C in a Fanconi anemia-like disorder. Mutation of RAD51C, encoding a protein involved in homologous recombination-mediated DNA repair, leads to hypersensitivity to DNA cross-linking agents.

Fiona Vaz
Helmut Hanenberg
Christopher G Mathew
Research18 Apr 2010
Nature Genetics

Volume: 42, P: 406-409
Germline mutations in breast and ovarian cancer pedigrees establish RAD51C as a human cancer susceptibility gene

Alfons Meindl and colleagues report heterozygous germline mutations in RAD51C in families with breast and ovarian cancer. Mutations were found in 1.3% of 480 pedigrees with breast and ovarian cancer, but not in 620 pedigrees with breast cancer only.

Alfons Meindl
Heide Hellebrand
Helmut Hanenberg
Research18 Apr 2010
Nature Genetics

Volume: 42, P: 410-414
The neuroanatomical–functional paradox in spinal cord injury

In this Perspective, the authors discuss the mechanisms underlying the complex relationship between lesion size and functional recovery after spinal cord injury, highlighting various complications that can limit the accuracy of outcome prediction in patients and in animal models.

Karim Fouad
Phillip G. Popovich
Jan M. Schwab
Reviews11 Dec 2020
Nature Reviews Neurology

Volume: 17, P: 53-62
Chronic oxidative stress adaptation in head and neck cancer cells generates slow-cyclers with decreased tumour growth in vivo

Julia Berner
Lea Miebach
Sander Bekeschus
ResearchOpen Access17 Jul 2023
British Journal of Cancer

Volume: 129, P: 869-883

Search

Synthetic mycobacterial molecular patterns partially complete Freund’s adjuvant

Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17–producing T cells

Speos: an ensemble graph representation learning framework to predict core gene candidates for complex diseases

A third vaccination with a single T cell epitope confers protection in a murine model of SARS-CoV-2 infection

Protective effect of TCR-mediated MAIT cell activation during experimental autoimmune encephalomyelitis

Inhibition of neuronal FLT3 receptor tyrosine kinase alleviates peripheral neuropathic pain in mice

A network of trans-cortical capillaries as mainstay for blood circulation in long bones

High-throughput single-cell activity-based screening and sequencing of antibodies using droplet microfluidics

Selective cytotoxic T-lymphocyte targeting of tumor immune escape variants

A Cre-inducible diphtheria toxin receptor mediates cell lineage ablation after toxin administration

Bassoon proteinopathy drives neurodegeneration in multiple sclerosis

FANCI is a second monoubiquitinated member of the Fanconi anemia pathway

Biallelic mutations in PALB2 cause Fanconi anemia subtype FA-N and predispose to childhood cancer

A Nonpeptide Oxytocin Receptor Agonist for a Durable Relief of Inflammatory Pain

Phylogeography of the second plague pandemic revealed through analysis of historical Yersinia pestis genomes

Antigen discovery unveils resident memory and migratory cell roles in antifungal resistance

S100B immunization triggers NFκB and complement activation in an autoimmune glaucoma model

Prognosis and quality of life in patients with locally advanced rectal cancer after abdominoperineal resection in the CAO/ARO/AIO-04 randomized phase 3 trial

Mutation of the RAD51C gene in a Fanconi anemia–like disorder

Germline mutations in breast and ovarian cancer pedigrees establish RAD51C as a human cancer susceptibility gene

The neuroanatomical–functional paradox in spinal cord injury

Chronic oxidative stress adaptation in head and neck cancer cells generates slow-cyclers with decreased tumour growth in vivo

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