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Showing 1–3 of 3 results
Advanced filters: Author: Marcel Renn Clear advanced filters

  • siRNA is used to silence expression of a specific gene and, if modified by a triphosphate at the 5′ end, will also activate the helicase Rig-I, leading to interferon production. Poeck et al. now combine both of these activities in a single siRNA to kill melanoma cells by crippling a crucial tumor cell survival pathway and triggering an interferon-dependent antitumor immune response (pages 1152–1153).

    • Hendrik Poeck
    • Robert Besch
    • Gunther Hartmann
    Research
    Nature Medicine
    Volume: 14, P: 1256-1263

  • The c-Jun transcription factor can mediate a cell's response to TNFa. Here, Riesenberg et al. show in melanoma cells that c-Jun has an inverse relationship with the key melanocyte transcription factor MITF and that high c-Jun levels contribute to melanoma heterogeneity and an inflammatory microenvironment.

    • Stefanie Riesenberg
    • Angela Groetchen
    • Michael Hölzel
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-16

  • A genetically engineered mouse model is used to determine the mechanism of acquired resistance to adoptive therapy with cytotoxic T cells specific for a melanocytic differentiation antigen; tumour necrosis factor (TNF)-α is identified as a crucial factor that causes reversible dedifferentiation of mouse and human melanoma cells.

    • Jennifer Landsberg
    • Judith Kohlmeyer
    • Thomas Tüting
    Research
    Nature
    Volume: 490, P: 412-416