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Showing 1–3 of 3 results
Advanced filters: Author: Marcelo Paez-Pereda Clear advanced filters

  • Histone deacetylases (HDACs) regulate energy metabolism in peripheral tissues, but whether HDACs expressed in the brain influence systemic metabolism is unknown. Here the authors show that hypothalamic HDAC5 expression is affected by the diet and HDAC5 regulates leptin sensitivity by deacetylating STAT3.

    • Dhiraj G. Kabra
    • Katrin Pfuhlmann
    • Paul T. Pfluger
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-12

  • Stress is recognized as risk factor for the development of type 2 diabetes. Here Balsevich et al. show that the stress responsive co-chaperone FKBP5 regulates glucose metabolism in mice by modulating AS160 phosphorylation, glucose transporter expression and muscle glucose uptake.

    • Georgia Balsevich
    • Alexander S. Häusl
    • Mathias V. Schmidt
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-12