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Showing 1–6 of 6 results
Advanced filters: Author: Marcin Golczak Clear advanced filters

  • Compounds containing a primary amino group can protect against light-induced retinal degeneration in a mouse model of Stargardt’s disease and age-related retinal degeneration by forming a transient Schiff base with all-trans-retinal, lowering its intracellular concentration and preventing accumulation of lipofuscin chromophores in the eye.

    • Akiko Maeda
    • Marcin Golczak
    • Krzysztof Palczewski
    Research
    Nature Chemical Biology
    Volume: 8, P: 170-178

  • Retinoid isomerase is a critical enzyme in the conversion of retinyl esters to 11-cis-retinol, a key step in the regeneration of visual pigments that mediate light perception. Structural, biochemical and modeling data using substrate analogs explain how this unusual reaction proceeds.

    • Philip D Kiser
    • Jianye Zhang
    • Krzysztof Palczewski
    Research
    Nature Chemical Biology
    Volume: 11, P: 409-415

  • Mutations that lead to misfolding of rhodopsin can cause retinitis pigmentosa. Here, the authors carry out a high throughput screen to identify a small molecule chaperone of rod opsin, and show that it protects mouse models of retinitis pigmentosa from retinal degeneration.

    • Yuanyuan Chen
    • Yu Chen
    • Krzysztof Palczewski
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-18

  • A crystal structure of a chimera composed of lipid-metabolizing transmembrane enzymes HRASLS3 and LRAT (which catalyzes esterification of vitamin A) identifies a quaternary structural rearrangement that coincides with formation of a three-dimensionally swapped dimer.

    • Marcin Golczak
    • Avery E Sears
    • Krzysztof Palczewski
    Research
    Nature Chemical Biology
    Volume: 11, P: 26-32

  • Tsybovsky et. al. report cryo-EM structures of tetrameric rat ALDH1L1 elucidating its architecture and domain interactions important for its functions. These findings emphasize the versatility of acyl/peptidyl carrier proteins in complex, highly dynamic enzymatic systems.

    • Yaroslav Tsybovsky
    • Valentin Sereda
    • Sergey A. Krupenko
    ResearchOpen Access
    Communications Biology
    Volume: 5, P: 1-13