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Showing 1–3 of 3 results
Advanced filters: Author: Marcin I Apostol Clear advanced filters

  • Degenerative diseases such as Alzheimer's or Parkinson's are associated with the misfolding of many diverse proteins, yet the amyloid fibrils formed by all these proteins are similar. David Eisenberg and colleagues have now identified 30 short fibril-forming peptides implicated in a range of amyloid diseases and have solved 13 of their atomic structures, revealing variations in one common feature — the 'steric zipper'.

    • Michael R. Sawaya
    • Shilpa Sambashivan
    • David Eisenberg
    Research
    Nature
    Volume: 447, P: 453-457

  • Prions can adopt a transmissible β-sheet-rich conformation and also form strains with different structural and biological properties. Polymorphic crystal structures of peptides from prion- and other amyloid-forming proteins suggest the structural basis for prion strains, revealing two potential mechanisms: packing and segmental polymorphism.

    • Jed J W Wiltzius
    • Meytal Landau
    • David Eisenberg
    Research
    Nature Structural & Molecular Biology
    Volume: 16, P: 973-978