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Showing 1–12 of 12 results
Advanced filters: Author: Marco Ballabio Clear advanced filters

  • Electrical excitability in neuroendocrine SCLC cells promotes tumour progression through action potential firing, increasing ATP demand and oxidative phosphorylation dependency, whereas non-neuroendocrine cells provide metabolic support, driving a tumour-autonomous cycle that enhances tumorigenesis and metastasis.

    • Paola Peinado
    • Marco Stazi
    • Leanne Li
    ResearchOpen Access
    Nature
    Volume: 639, P: 765-775

  • Medina, Ballabio and colleagues report that calcium release from the lysosome stimulates calcineurin, which dephosphorylates and activates TFEB. These findings reveal a central role for calcium signalling in autophagy and lysosome homeostasis.

    • Diego L. Medina
    • Simone Di Paola
    • Andrea Ballabio
    Research
    Nature Cell Biology
    Volume: 17, P: 288-299

  • Mutations in the RRAGD gene are causative of an autosomal dominant disorder characterized by kidney tubulopathy and cardiomyopathy. Here, the authors identify a new RRAGD P88L mutation, demonstrating that all the identified RRAGD mutations inhibit the nuclear translocation of MiT/TFE transcription factors, resulting in defective responses to lysosomal or mitochondrial damage.

    • Irene Sambri
    • Marco Ferniani
    • Andrea Ballabio
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-13

  • The Transcription Factor EB (TFEB) is known to regulate cellular homeostasis and energy metabolism, but its role in cell fate determination in the liver is unknown. Here, the authors show that TFEB regulates the progenitor/cholangiocyte lineage and that its depletion prevents tissue recovery upon injury.

    • Nunzia Pastore
    • Tuong Huynh
    • Andrea Ballabio
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-14

  • M. Valentini et al. study superconducting quantum interference devices (SQUIDs) where the weak link of the Josephson junctions is a germanium 2D hole gas. They report signatures of the tunneling of pairs of Cooper pairs. For a particular microwave drive power, they observe a 100% efficient superconducting diode effect.

    • Marco Valentini
    • Oliver Sagi
    • Georgios Katsaros
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-10

  • Semiconductors that display spontaneous magnetization are attractive for spintronic applications. Here the authors report a p-type semiconducting layered metal–organic framework that displays a room temperature carrier mobility of 15 ± 2 cm2 V−1 s−1 as well as long-range magnetic correlations.

    • Chongqing Yang
    • Renhao Dong
    • Xinliang Feng
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-9

  • Group 3 medulloblastoma (MB) is considered one of the most aggressive forms of this cancer. Here, the authors show that Otx2 and c-MYC oncogenes can drive Group 3 MB formation in mouse and human cerebellar organoids while SMARCA4 overexpression or a EZH2-specific inhibitor can inhibit tumorigenesis.

    • Claudio Ballabio
    • Marica Anderle
    • Luca Tiberi
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-18

  • Cancer of unknown primary (CUP) is a mysterious malignancy featuring metastatic dissemination in the absence of a recognizable primary tumor. By characterizing CUP cancer stem cells we show that self-sustained long-term propagation and sensitivity to MEK inhibition are CUP common features.

    • Federica Verginelli
    • Alberto Pisacane
    • Carla Boccaccio
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-16

  • RagGTPases (Rags) play an essential role in the regulation of cell metabolism by controlling the activities of both mechanistic target of rapamycin complex 1 (mTORC1) and Transcription factor EB (TFEB). Here the authors review several diseases, termed ragopathies, that are associated with Rag dysfunction.

    • Irene Sambri
    • Marco Ferniani
    • Andrea Ballabio
    ReviewsOpen Access
    Nature Communications
    Volume: 15, P: 1-10

  • di Ronza et al. identify CLN8 as a cargo receptor for lysosomal enzymes required for their endoplasmic-reticulum-to-Golgi transport, linking Batten disease caused by CLN8 mutations to defects in organelle biogenesis.

    • Alberto di Ronza
    • Lakshya Bajaj
    • Marco Sardiello
    Research
    Nature Cell Biology
    Volume: 20, P: 1370-1377