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Researchers demonstrate a terahertz quantum cascade laser operating in a regime of active mode-locking by modulating its bias current with a radiofrequency synthesizer. This technique allows coherent sampling of the terahertz electric field as well as control over the laser's carrier–envelope phase shift.

While most quantum optical techniques reveal either the wave or particle nature of light, weak-field homodyne detection combines wave- and particle-like descriptions. Here, Donati et al.employ this hybrid detection scheme to study the coherence between photon number states across two-mode entangled states.

A general approach to simplifying quantum logic circuits—the ‘programs’ of quantum computers—is described and demonstrated on a platform based on photonic qubits.

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

Fish show an amazing variety of colour patterns; however, the genetic basis for the evolution of this diversity is largely unexplored. Here, the authors identify the potassium channel gene Kcnj13 as evolved to contribute to differences in colour patterns between closely related Danio fish species.

Quantifying rapidly progressing three-dimensional forces generated by cells remains a major challenge in mechanobiology. Here, the authors show that combining traction force microscopy with astigmatic imaging permits sensitive out-of-plane force estimation on the second timescale.

Hundreds of genetic loci associated with age at menopause, combined with experimental evidence in mice, highlight mechanisms of reproductive ageing across the lifespan.

Quantifying rapid and small cellular forces is a major challenge in mechanobiology. Here, the authors show a >2-fold spatially and >10-fold temporally force sampling improvement combining traction force microscopy with total internal reflection fluorescence super-resolution structured illumination microscopy.

Phase estimation is an important element of quantum metrology, but the influence of noise cannot always be well characterized. Vidrighin et al.analyse and experimentally demonstrate methods providing simultaneous estimation of a phase shift and the amplitude of phase diffusion at the quantum limit.

Thyroid dysfunction is a common public health problem and associated with cardiovascular co-morbidities. Here, the authors carry out genome-wide meta-analysis for thyroid hormone (TH) levels, hyper- and hypothyroidism and identify SLC17A4 as a TH transporter and AADAT as a TH metabolizing enzyme.

Castro, Shindyapina et al. explore how aging promotes B cell lymphoma in mice, identifying a population of age-associated clonal B cells that expands through mutation, c-Myc activation and epigenetic alterations to drive age-associated malignancy.

Association analyses in over 1 million individuals identify 535 new loci influencing blood pressure traits. The results provide new insights into blood pressure regulation and highlight shared genetic architecture between blood pressure and lifestyle exposures.

Teleportation of a photonic qubit is demonstrated on a reconfigurable photonic chip. All of the key elements of the teleportation protocol are performed. The average fidelity for the three linearly independent quantum states is higher than the classical limit, which certifies the capability of teleporting a general quantum state.

The approximately 5-Gb tuatara (Sphenodon punctatus) genome assembly provides a resource for analysing amniote evolution, and highlights the imperative for meaningful cultural engagement with Indigenous communities in genome-sequencing endeavours.

For future optical information processing applications, including quantum computing, ever more complex quantum photonic devices are needed. Metcalf et al. present an integrated photonic device capable of three-photon quantum operation, including Hong-Ou-Mandel-type interference between three photons.

Both rare and common variants contribute to the aetiology of complex traits such as type 2 diabetes (T2D). Here, the authors examine the effect of coding variation on glycaemic traits and T2D, and identify low-frequency variation in GLP1Rsignificantly associated with these traits.

Romani et al. report that cells on soft extracellular matrix have increased mitochondrial fission, with subsequent production of mitochondrial reactive oxygen species and NRF2, which may increase resistance to reactive oxygen species-dependent chemotherapy drugs in breast cancer cells in vitro and in mouse lungs.

Very long baseline interferometry is used to compare two optical clocks located in Japan and Italy through the observation of extragalactic radio sources. This approach overcomes limitations of the performance of satellite transfer techniques.

BAG3 is found in the serum of pancreatic cancer patients and can be used as a marker of disease, but its role in cancer is unclear. Here, the authors show that BAG3 secreted from tumour cells binds to and activates macrophages, which in turn promotes cell growth, and an antibody blocking BAG3 binding reduces tumour formation in mice.

John Perry, Ken Ong and colleagues analyze genotype data on ∼370,000 women and identify 389 independent signals that associate with age at menarche, implicating ∼250 genes. Their analyses suggest causal inverse associations, independent of BMI, between puberty timing and risks for breast and endometrial cancers in women and prostate cancer in men.

Mark Caulfield, Paul Elliott and colleagues use data from the UK Biobank to perform genome-wide association analysis for blood pressure traits. They identify and validate 107 novel loci and highlight new biological pathways for potential therapeutic intervention for hypertension.

Combined analysis of proton-proton collision data from the Large Hadron Collider at CERN by the CMS and LHCb collaborations leads to the observation of the extremely rare decay of the strange B meson into muons; the result is compatible with the standard model of particle physics, and does not show any signs of new physics, such as supersymmetry.

An atomic clock has been deployed on a field measurement campaign to determine the height of a mountain location 1,000 m above sea level, returning a value that is in good agreement with state-of-the-art geodesy.

The ‘onion-like’ stratification of the two lobes of the comet 67P/Churyumov–Gerasimenko reveals that its unusual shape is the result of a gentle collision merging two kilometre-sized objects in the early stages of the Solar System.

The size and spatial distribution of pits on comet 67P/Churyumov–Gerasimenko, which are active and probably created by a sinkhole process, imply that large heterogeneities exist in the physical, structural or compositional properties of the first few hundred metres below the current cometary surface.