We synthesized the poly(N,N-dimethylacrylamide)-based resin R2 and the new TentaGel resins T3 and T4 obtained via immobilization of substrate-like inhibitors of copper amine oxidases (CAOs) onto commercial TentaGel S-Br. We used polyacrylamide gel electrophoresis experiments to determine the capability of the prepared resins to capture plasma amine oxidase (PAO) and diamine oxidase (DAO), members of the CAO family. The poly(N,N-dimethylacrylamide)-based resin R2 proved to be the first insoluble polymeric material capable of capturing enzymes of the CAO family such as PAO and DAO.
- Marco Pocci
- Silvana Alfei
- Vincenzo Bertini
