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Showing 1–8 of 8 results
Advanced filters: Author: Marco Seehawer Clear advanced filters

  • Seehawer et al. show that deletion of Kmt2c or Kmt2d promotes brain metastasis in mouse models of triple-negative breast cancer due to altered KDM6A activity and upregulated MMP3 expression, which may constitute a potential therapeutic target.

    • Marco Seehawer
    • Zheqi Li
    • Kornelia Polyak
    ResearchOpen Access
    Nature Cell Biology
    Volume: 26, P: 1165-1175

  • The tumour microenvironment determines which type of liver cancer develops, with transformed hepatocytes giving rise to intrahepatic cholangiocarcinoma or hepatocellular carcinoma depending or whether they are surrounded by cells undergoing necroptosis or apoptosis.

    • Marco Seehawer
    • Florian Heinzmann
    • Lars Zender
    Research
    Nature
    Volume: 562, P: 69-75

  • TGFβ signalling is reported to regulate hormone-responsive mammary epithelial progenitors that are associated with breast cancer risk. Here, the authors find that short-term TGFBR1 inhibition prevents tumour formation in rat breast cancer models and identify a TGFBR1 inhibition-responsive sub-population of mammary epithelial cells, which is associated with human breast cancer risk.

    • Maša Alečković
    • Simona Cristea
    • Kornelia Polyak
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-16

  • The definition of biomarkers to predict therapy responses to immune-checkpoint inhibitors represent an unmet clinical need. Here the authors provide evidences that platelet-derived PD-L1 could serve as a prognostic and predictive biomarker in patients with non-small cell lung cancer.

    • Clemens Hinterleitner
    • Jasmin Strähle
    • Lars Zender
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-16

  • In this Review, Polyak and colleagues discuss cellular and microenvironmental mechanisms that contribute to intratumour heterogeneity and how this affects immune escape and tumour progression.

    • Zheqi Li
    • Marco Seehawer
    • Kornelia Polyak
    Reviews
    Nature Cell Biology
    Volume: 24, P: 1192-1201

  • This Review discusses the unique and complex immunological and metabolic features of the liver, from the precancerous stage through to oncological transformation and metastasis. Strategies for targeting this niche are also considered.

    • Xin Li
    • Pierluigi Ramadori
    • Mathias Heikenwalder
    Reviews
    Nature Reviews Cancer
    Volume: 21, P: 541-557