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Showing 51–99 of 99 results

Advanced filters: Author: Marcus R Clark Clear advanced filters

BRWD1 orchestrates epigenetic landscape of late B lymphopoiesis

B-cell development is tightly regulated by transcription programs that are coordinated by transcription factors (TF) and locus accessibility. Here the authors show that, in mice and humans, the epigenetic reader BRWD1 inhibits and promotes the accessibility of enhancers for early and late B lymphopoiesis, respectively.

Malay Mandal
Mark Maienschein-Cline
Marcus R. Clark
ResearchOpen Access24 Sept 2018
Nature Communications

Volume: 9, P: 1-15
Chimeric mouse tumor models reveal differences in pathway activation between ERBB family– and KRAS-dependent lung adenocarcinomas

One reason for the high failure rate of experimental cancer therapies is that mouse tumor models do not accurately predict the behavior of human cancers. Zhou et al. provide more realistic models by generating chimeric mice bearing drug-inducible, tissue-specific oncogenes.

Yinghui Zhou
William M Rideout II
Joerg Heyer
Research01 Jan 2010
Nature Biotechnology

Volume: 28, P: 71-78
100 GATED MAGNETIC RESONANCE IMAGING OF THE IN VIVO HEART: DETERMINATION OF LEFT VENTRICULAR MASS IN DOGS

Michael Florentine
Cynthia Grosskreutz
Edward B Clark
Research01 Apr 1985
Pediatric Research

Volume: 19, P: 127
Developmental changes in the accessible chromatin, transcriptome and Ascl1-binding correlate with the loss in Müller Glial regenerative potential

Leah S. VandenBosch
Stefanie G. Wohl
Thomas A. Reh
ResearchOpen Access12 Aug 2020
Scientific Reports

Volume: 10, P: 1-18
A deep learning framework identifies dimensional representations of Alzheimer’s Disease from brain structure

Alzheimer’s disease is heterogeneous in its neuroimaging and clinical phenotypes. Here the authors present a semi-supervised deep learning method, Smile-GAN, to show four neurodegenerative patterns and two progression pathways providing prognostic and clinical information.

Zhijian Yang
Ilya M. Nasrallah
Balebail Ashok Raj
ResearchOpen Access03 Dec 2021
Nature Communications

Volume: 12, P: 1-15
The BIN1 rs744373 SNP is associated with increased tau-PET levels and impaired memory

The BIN1 SNP rs744373 is associated with higher CSF tau and phosphorylated tau levels. Here the authors show, using PET imaging, that this SNP is associated with tau accumulation in the brain as well as impaired memory in older individuals without dementia.

Nicolai Franzmeier
Anna Rubinski
Ansgar J. Furst
ResearchOpen Access16 Apr 2019
Nature Communications

Volume: 10, P: 1-12
A self-reinforcing regulatory network triggered by limiting IL-7 activates pre-BCR signaling and differentiation

Cycling and cell cycle–arrested pre-B cells both express pre-BCRs, but whether qualitative differences exist in downstream signaling pathways remains controversial. Singh and colleagues show that differences in expression of the adaptor BLNK underlie functional distinctions in pre-BCR signaling.

Kyoko Ochiai
Mark Maienschein-Cline
Harinder Singh
Research22 Jan 2012
Nature Immunology

Volume: 13, P: 300-307
Non-coding variability at the APOE locus contributes to the Alzheimer’s risk

Several studies show that APOE-ε4 coding variants are associated with Alzheimer’s disease (AD) risk. Here, Zhou et al. perform fine-mapping of the APOE region and find AD risk haplotypes with non-coding variants in the PVRL2 and APOC1 regions that are associated with relevant endophenotypes.

Xiaopu Zhou
Yu Chen
Nancy Y. Ip
ResearchOpen Access25 Jul 2019
Nature Communications

Volume: 10, P: 1-16
Flippin' lipids

B cell generation is disturbed in four newly identified mouse mutants bearing X-linked mutations in the gene encoding the ATPase ATP11C. These findings suggest that the distribution of membrane phospholipids confers a yet-to-be delineated developmental signal.

Marcus R Clark
News & Views19 Apr 2011
Nature Immunology

Volume: 12, P: 373-375
An unusual case of ocular self-injury

Marcus Lim
David Kent
David Clark
Correspondence01 Sept 2001
Eye

Volume: 15, P: 660-661
Human 'brite/beige' adipocytes develop from capillary networks, and their implantation improves metabolic homeostasis in mice

Human beige adipocyte precursors associated with capillary networks proliferate in response to angiocrines, and when activated in vitro and transplanted into mice, they improve glucose intolerance.

So Yun Min
Jamie Kady
Silvia Corvera
Research25 Jan 2016
Nature Medicine

Volume: 22, P: 312-318
Author Correction: Genotyping, sequencing and analysis of 140,000 adults from Mexico City

Andrey Ziyatdinov
Jason Torres
Roberto Tapia-Conyer
Amendments and CorrectionsOpen Access08 Feb 2024
Nature

Volume: 626, P: E18
The IDEAL framework for surgical robotics: development, comparative evaluation and long-term monitoring

To guide the safe implementation of the next generation of surgical robots, the IDEAL Robotics Colloquium provides recommendations for their evaluation throughout the product life cycle—considering multiple perspectives within and beyond the surgical team.

Hani J. Marcus
Pedro T. Ramirez
Arsenio Paez
Reviews19 Jan 2024
Nature Medicine

Volume: 30, P: 61-75
The impact of rare variation on gene expression across tissues

The authors show that rare genetic variants contribute to large gene expression changes across diverse human tissues and provide an integrative method for interpretation of rare variants in individual genomes.

Xin Li
Yungil Kim
Stephen B. Montgomery
ResearchOpen Access12 Oct 2017
Nature

Volume: 550, P: 239-243
Landscape of X chromosome inactivation across human tissues

Multiple transcriptome approaches, including single-cell sequencing, demonstrate that escape from X chromosome inactivation is widespread and occasionally variable between cells, chromosomes, and tissues, resulting in sex-biased expression of at least 60 genes and potentially contributing to sex-specific differences in health and disease.

Taru Tukiainen
Alexandra-Chloé Villani
Daniel G. MacArthur
ResearchOpen Access12 Oct 2017
Nature

Volume: 550, P: 244-248
PI3Kδ: Too much of a good thing

PI3Kδ regulates adaptive immune thresholds and limits immunity to endogenous microbiota.

Domenick E. Kennedy
Marcus R. Clark
News & Views20 Aug 2018
Nature Immunology

Volume: 19, P: 910-911
Author Correction: Tree rings reveal globally coherent signature of cosmogenic radiocarbon events in 774 and 993 CE

Ulf Büntgen
Lukas Wacker
Giles H. F. Young
Amendments and CorrectionsOpen Access17 Dec 2018
Nature Communications

Volume: 9, P: 1-2
T cell and antibody responses induced by a single dose of ChAdOx1 nCoV-19 (AZD1222) vaccine in a phase 1/2 clinical trial

A single dose of the ChAdOx1 nCoV-19 vaccine elicits antibodies and cytokine-producing T cells that might help control or prevent SARS-CoV-2 infection.

Katie J. Ewer
Jordan R. Barrett
Elizabeth Stafford
Research17 Dec 2020
Nature Medicine

Volume: 27, P: 270-278
GAIN2 trial overall survival with intense versus tailored dose dense chemotherapy in early breast cancer

Volker Möbus
Hans-Joachim Lück
Sibylle Loibl
ResearchOpen Access30 Jul 2024
npj Breast Cancer

Volume: 10, P: 1-10
Author Correction: T cell and antibody responses induced by a single dose of ChAdOx1 nCoV-19 (AZD1222) vaccine in a phase 1/2 clinical trial

Katie J. Ewer
Jordan R. Barrett
Elizabeth Stafford
Amendments and Corrections21 May 2021
Nature Medicine

Volume: 27, P: 1116
Author Correction: Phase 1/2 trial of SARS-CoV-2 vaccine ChAdOx1 nCoV-19 with a booster dose induces multifunctional antibody responses

Jordan R. Barrett
Sandra Belij-Rammerstorfer
Dalila Zizi
Amendments and Corrections06 May 2021
Nature Medicine

Volume: 27, P: 1113
Effects of remote ischemic preconditioning on early markers of intestinal injury in experimental hemorrhage in rats

Stefan Hof
Hendrik Untiedt
Richard Truse
ResearchOpen Access05 Jun 2024
Scientific Reports

Volume: 14, P: 1-16
Construction, Bacterial Expression and Characterization of a Bifunctional Single–Chain Antibody–Phosphatase Fusion Protein Targeted to the Human ERBB–2 Receptor

Winfried Wels
Ina-Maria Harwerth
Nancy E. Hynes
Research01 Oct 1992
Bio/Technology

Volume: 10, P: 1128-1132
Orchestrating B cell lymphopoiesis through interplay of IL-7 receptor and pre-B cell receptor signalling

Developing B cells that have successfully expressed a pre-B cell receptor (pre-BCR) undergo clonal expansion, but must exit the cell cycle before rearranging their immunoglobulin light chain loci. The authors discuss how signalling through the interleukin-7 receptor and BCR is coordinated in a mutually exclusive manner to ensure the production of mature B cells without risking leukaemic transformation.

Marcus R. Clark
Malay Mandal
Harinder Singh
Reviews31 Dec 2013
Nature Reviews Immunology

Volume: 14, P: 69-80
Lack of association of the COMT (Val^158/108 Met) gene and schizophrenia: a meta-analysis of case–control studies

M R Munafò
L Bowes
J Flint
Research12 Apr 2005
Molecular Psychiatry

Volume: 10, P: 765-770
Publisher Correction: Genomic reconstruction of the SARS CoV-2 epidemic in England

Harald S. Vöhringer
Theo Sanderson
Moritz Gerstung
Amendments and CorrectionsOpen Access07 Jun 2022
Nature

Volume: 606, P: E18
Spin-orbit coupled spin-polarised hole gas at the CrSe₂-terminated surface of AgCrSe₂

Gesa-R. Siemann
Seo-Jin Kim
Phil D. C. King
ResearchOpen Access21 Oct 2023
npj Quantum Materials

Volume: 8, P: 1-7
Author Correction: Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network

Mathys Grapotte
Manu Saraswat
Charles-Henri Lecellier
Amendments and CorrectionsOpen Access01 Mar 2022
Nature Communications

Volume: 13, P: 1
Genetics in geographically structured populations: defining, estimating and interpreting F_ST

F_STdescribes the processes that lead to genetic differentiation among and within populations and is widely used in population and evolutionary genetics. This article describes the meaning ofF_STand how it should be estimated and interpreted.

Kent E. Holsinger
Bruce S. Weir
Reviews01 Sept 2009
Nature Reviews Genetics

Volume: 10, P: 639-650
Lack of genetic differentiation among widely spaced subpopulations of a butterfly with home range behaviour

Marcus R Kronforst
Theodore H Fleming
Research01 Feb 2001
Heredity

Volume: 86, P: 243-250
Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk

Richard Houlston and colleagues report a genome-wide association study for colorectal cancer. They report three loci newly associated with colorectal cancer, bringing the total number of common susceptibility loci to 20.

Malcolm G Dunlop
Sara E Dobbins
Richard S Houlston
Research27 May 2012
Nature Genetics

Volume: 44, P: 770-776
Profiling gut microbiota and bile acid metabolism in critically ill children

Iain Robert Louis Kean
Joseph Wagner
Nazima Pathan
ResearchOpen Access21 Jun 2022
Scientific Reports

Volume: 12, P: 1-12
Association of polygenic score for major depression with response to lithium in patients with bipolar disorder

Azmeraw T. Amare
Klaus Oliver Schubert
Bernhard T. Baune
Research16 Mar 2020
Molecular Psychiatry

Volume: 26, P: 2457-2470
New clinical and biological insights from the international TARGIT-A randomised trial of targeted intraoperative radiotherapy during lumpectomy for breast cancer

Jayant S. Vaidya
Max Bulsara
Jeffrey S. Tobias
ResearchOpen Access25 May 2021
British Journal of Cancer

Volume: 125, P: 380-389
Does measurement instrument moderate the association between the serotonin transporter gene and anxiety-related personality traits? A meta-analysis

M R Munafò
T Clark
J Flint
Research14 Dec 2004
Molecular Psychiatry

Volume: 10, P: 415-419
Habitat degradation impacts black howler monkey (Alouatta pigra) gastrointestinal microbiomes

Katherine R Amato
Carl J Yeoman
Steven R Leigh
Research14 Mar 2013
The ISME Journal

Volume: 7, P: 1344-1353
Publisher Correction: SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway

Brian J. Willett
Joe Grove
Emma C. Thomson
Amendments and CorrectionsOpen Access16 Sept 2022
Nature Microbiology

Volume: 7, P: 1709
Author Correction: Supporting US public health experts

Ron Cohen
Cedric Francois
Sandy Zweifach
Amendments and Corrections17 Dec 2020
Nature Biotechnology

Volume: 39, P: 115
Aqueous humour interleukin-6 and vision outcomes with anti-vascular endothelial growth factor therapy

Yasir Jamal Sepah
Diana V. Do
P. Abraham
ResearchOpen Access15 Apr 2024
Eye

Volume: 38, P: 1755-1761
Deep learning-based polygenic risk analysis for Alzheimer’s disease prediction

Zhou et al. utilise deep learning to improve polygenic risk analysis for Alzheimer’s disease. Their computational approach outperforms existing statistical methods and helps to identify potential biological mechanisms of Alzheimer’s disease risk.

Xiaopu Zhou
Yu Chen
Nancy Y. Ip
ResearchOpen Access06 Apr 2023
Communications Medicine

Volume: 3, P: 1-20
COVID-19 due to the B.1.617.2 (Delta) variant compared to B.1.1.7 (Alpha) variant of SARS-CoV-2: a prospective observational cohort study

Kerstin Kläser
Erika Molteni
Emma L. Duncan
ResearchOpen Access28 Jun 2022
Scientific Reports

Volume: 12, P: 1-17
Supporting US public health experts

Ron Cohen
Cedric Francois
Sandy Zweifach
Correspondence25 Nov 2020
Nature Biotechnology

Volume: 38, P: 1381-1384
Gene and pathway level analyses of germline DNA-repair gene variants and prostate cancer susceptibility using the iCOGS-genotyping array

Edward J Saunders
Tokhir Dadaev
Zsofia Kote-Jarai
ResearchOpen Access10 Mar 2016
British Journal of Cancer

Volume: 114, P: 945-952
Promise and pitfalls in the meta-analysis of genetic association studies: a response to Sen and Schinka

M R Munafò
T Clark
J Flint
Research28 Jun 2005
Molecular Psychiatry

Volume: 10, P: 895-897
Genomic epidemiology of SARS-CoV-2 in a university outbreak setting and implications for public health planning

Sema Nickbakhsh
Joseph Hughes
Alison Smith-Palmer
ResearchOpen Access19 Jul 2022
Scientific Reports

Volume: 12, P: 1-17
Carbon flow from volcanic CO₂ into soil microbial communities of a wetland mofette

Felix Beulig
Verena B Heuer
Kirsten Küsel
Research12 Sept 2014
The ISME Journal

Volume: 9, P: 746-759
Four consecutive yearly point-prevalence studies in Wales indicate lack of improvement in sepsis care on the wards

Maja Kopczynska
Harry Unwin
Judith E. Hall
ResearchOpen Access10 Aug 2021
Scientific Reports

Volume: 11, P: 1-12
Association of the NRG1 gene and schizophrenia: a meta-analysis

M R Munafò
D L Thiselton
J Flint
Reviews07 Mar 2006
Molecular Psychiatry

Volume: 11, P: 539-546
Genetic Polymorphisms and Personality in Healthy Adults: A systematic review and meta-analysis

M R Munafò
T G Clark
J Flint
Special Features16 Jun 2003
Molecular Psychiatry

Volume: 8, P: 471-484

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