Nature Search

Gut microbial factors predict disease severity in a mouse model of multiple sclerosis

Gut microbiota factors including IgA coating can predict disease severity in a mouse model of multiple sclerosis.

Alex Steimle
Mareike Neumann
Mahesh S. Desai
ResearchOpen Access15 Jul 2024
Nature Microbiology

Volume: 9, P: 2244-2261
Guard cell endomembrane Ca²⁺-ATPases underpin a ‘carbon memory’ of photosynthetic assimilation that impacts on water-use efficiency

An expanded OnGuard platform incorporates feedback between CO₂ concentration, photosynthesis and stomatal dynamics to connect molecular mechanisms with gas exchange in the leaf. Modelling and experimental data highlight the importance of intracellular calcium stores and calcium pumps in a response latency with environmental fluctuations.

Mareike Jezek
Fernanda A. L. Silva-Alvim
Michael R. Blatt
Research29 Jul 2021
Nature Plants

Volume: 7, P: 1301-1313
Effects of profit-driven cropland expansion and conservation policies

Understanding the various and multiple trade-offs of land-use changes and cropland expansion can contribute to more sustainable policies. A study explores future scenarios of cropland expansion along with the trade-offs in agricultural production and markets, biodiversity and CO₂ emissions.

Julia M. Schneider
Ruth Delzeit
Florian Zabel
Research13 Aug 2024
Nature Sustainability

Volume: 7, P: 1335-1347
AMPK-dependent activation of the Cyclin Y/CDK16 complex controls autophagy

AMPK integrates information about a cell’s energy status to inform decisions about cellular processes, including autophagy. Here the authors identify cyclin Y as an AMPK substrate, which phosphorylates cyclin Y and promotes its interaction with CDK16 to stimulate autophagy.

Marc Dohmen
Sarah Krieg
Jörg Vervoorts
ResearchOpen Access25 Feb 2020
Nature Communications

Volume: 11, P: 1-18
Akkermansia muciniphila exacerbates food allergy in fibre-deprived mice

The gut commensal Akkermansia muciniphila regulates food allergy symptoms in a diet-dependent manner in mice.

Amy Parrish
Marie Boudaud
Mahesh S. Desai
ResearchOpen Access11 Sept 2023
Nature Microbiology

Volume: 8, P: 1863-1879
Telomere length dynamics measured by flow-FISH in patients with obesity undergoing bariatric surgery

Benjamin Rolles
Monica S. V. Ferreira
Mareike Tometten
ResearchOpen Access06 Jan 2023
Scientific Reports

Volume: 13, P: 1-8
Alveolar regeneration through a Krt8+ transitional stem cell state that persists in human lung fibrosis

Injury repair is characterized by the generation of transient cell states important for tissue recovery. Here, the authors present a single cell RNA-seq map of recovery from bleomycin lung injury in mice and uncover a Krt8+ transitional stem cell state that precedes the regeneration of AT1 cells and persists in human lung fibrosis.

Maximilian Strunz
Lukas M. Simon
Herbert B. Schiller
ResearchOpen Access16 Jul 2020
Nature Communications

Volume: 11, P: 1-20
Inhibition of LTβR signalling activates WNT-induced regeneration in lung

Blockade of lymphotoxin β-receptor (LTβR) signalling restores WNT signalling and epithelial repair in a model of chronic obstructive pulmonary disease.

Thomas M. Conlon
Gerrit John-Schuster
Ali Önder Yildirim
Research04 Nov 2020
Nature

Volume: 588, P: 151-156
Transcriptional plasticity promotes primary and acquired resistance to BET inhibition

BET bromodomain inhibitors are being explored as potential therapeutics in cancer; here, AML cells are shown to evade sensitivity to BET inhibition through rewiring the transcriptional regulation of BRD4 target genes such as MYC in a process that is facilitated by suppression of PRC2 and WNT signalling activation.

Philipp Rathert
Mareike Roth
Johannes Zuber
Research14 Sept 2015
Nature

Volume: 525, P: 543-547
Interactions of commensal and pathogenic microorganisms with the intestinal mucosal barrier

The first line of host defence against both encroaching commensal bacteria and invading enteric pathogens is the intestinal mucosal barrier, which is composed of epithelial cells and a host-secreted mucous layer. In this Review, Martens and colleagues discuss the complex interactions of commensal and pathogenic microorganisms with the intestinal mucosal barrier.

Eric C. Martens
Mareike Neumann
Mahesh S. Desai
Reviews14 Jun 2018
Nature Reviews Microbiology

Volume: 16, P: 457-470

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Gut microbial factors predict disease severity in a mouse model of multiple sclerosis

Guard cell endomembrane Ca²⁺-ATPases underpin a ‘carbon memory’ of photosynthetic assimilation that impacts on water-use efficiency

Effects of profit-driven cropland expansion and conservation policies

AMPK-dependent activation of the Cyclin Y/CDK16 complex controls autophagy

Akkermansia muciniphila exacerbates food allergy in fibre-deprived mice

Telomere length dynamics measured by flow-FISH in patients with obesity undergoing bariatric surgery

Alveolar regeneration through a Krt8+ transitional stem cell state that persists in human lung fibrosis

Inhibition of LTβR signalling activates WNT-induced regeneration in lung

Transcriptional plasticity promotes primary and acquired resistance to BET inhibition

Interactions of commensal and pathogenic microorganisms with the intestinal mucosal barrier

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