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Showing 1–6 of 6 results
Advanced filters: Author: Marena I. Trinidad Clear advanced filters

  • Generating RNA sequences with improved function remains challenging. Here, authors present an RNA database for RNA structural and functional analysis. They use this database and the RNA generative models to identify RNA mutations that increase the thermostability of a bacterial ribosome.

    • Yekaterina Shulgina
    • Marena I. Trinidad
    • Jamie H. D. Cate
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-17

  • The delivery of CRISPR RNPs has potential advantages over other genome editing approaches, including reduced off-target editing and reduced immunogenicity. Here the authors report self-deliverable Cas9 RNPs capable of robustly editing cultured cells in vitro and the mouse brain upon direct injections.

    • Kai Chen
    • Elizabeth C. Stahl
    • Jennifer A. Doudna
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-11

  • Prioritising genes as potential drug targets is challenging and often unsuccessful once testing efficacy in humans. Here, the authors propose an approach to identifying drug targets that uses evidence from gain- or loss-of-function mutations associated with bidirectional effects on phenotypes.

    • Karol Estrada
    • Steven Froelich
    • Lon R. Cardon
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-11

  • The bacterial Csm complex efficiently knocks down eukaryotic nuclear and cytoplasmic RNAs.

    • David Colognori
    • Marena Trinidad
    • Jennifer A. Doudna
    ResearchOpen Access
    Nature Biotechnology
    Volume: 41, P: 1256-1264