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Correction: Corrigendum: Rare cell variability and drug-induced reprogramming as a mode of cancer drug resistance

Sydney M. Shaffer
Margaret C. Dunagin
Arjun Raj
Amendments and Corrections21 Feb 2018
Nature

Volume: 555, P: 274
CTCF blocks antisense transcription initiation at divergent promoters

Luan et al. find that CTCF shapes the transcriptional landscape in part by suppressing the initiation of upstream antisense transcription at hundreds of divergent gene promoters.

Jing Luan
Marit W. Vermunt
Gerd A. Blobel
Research11 Nov 2022
Nature Structural & Molecular Biology

Volume: 29, P: 1136-1144
Diverse clonal fates emerge upon drug treatment of homogeneous cancer cells

Anti-cancer treatment often results in a subset of the clonal cell population developing resistance to therapy, with resistant cells displaying a diversity of fate types resulting from the intrinsic variability among the clonal population before treatment.

Yogesh Goyal
Gianna T. Busch
Arjun Raj
Research19 Jul 2023
Nature

Volume: 620, P: 651-659
LADL: light-activated dynamic looping for endogenous gene expression control

A fusion of CIBN to dCas9 and a Cry2 bridge enables blue-light-inducible long-range chromatin loops.

Ji Hun Kim
Mayuri Rege
Jennifer E. Phillips-Cremins
Research24 Jun 2019
Nature Methods

Volume: 16, P: 633-639
Tumor-associated B-cells induce tumor heterogeneity and therapy resistance

Resistance to BRAFV600E inhibitors often occurs in melanoma patients. Here, the authors describe a potential mechanism of acquired drug resistance mediated by tumor-associated B cells-derived IGF-1.

Rajasekharan Somasundaram
Gao Zhang
Stephan N. Wagner
ResearchOpen Access19 Sept 2017
Nature Communications

Volume: 8, P: 1-16
Single-cell differences in matrix gene expression do not predict matrix deposition

Regenerative tissue engineering with mesenchymal stem cells is hampered by bulk methods of assessing differentiation status and a general assumption that expression of individual markers of stem cell differentiation correlate with functional capacity. Here the authors debunk this assumption by applying single-cell techniques to disassociate aggrecan mRNA abundance and matrix deposition.

Allison J. Cote
Claire M. McLeod
Robert L. Mauck
ResearchOpen Access03 Mar 2016
Nature Communications

Volume: 7, P: 1-13
ClampFISH detects individual nucleic acid molecules using click chemistry–based amplification

Sensitive detection of individual RNA and DNA molecules is achieved by exponentially amplifying the fluorescence signal.

Sara H Rouhanifard
Ian A Mellis
Arjun Raj
Research12 Nov 2018
Nature Biotechnology

Volume: 37, P: 84-89
The long non-coding RNA Morrbid regulates Bim and short-lived myeloid cell lifespan

The long non-coding RNA Morrbid controls myeloid cell lifespan and regulates apoptosis by repressing the adjacent pro-apoptotic Bcl2l11 gene in cis.

Jonathan J. Kotzin
Sean P. Spencer
Jorge Henao-Mejia
Research15 Aug 2016
Nature

Volume: 537, P: 239-243
Rare cell variability and drug-induced reprogramming as a mode of cancer drug resistance

Through drug exposure, a rare, transient transcriptional program characterized by high levels of expression of known resistance drivers can get ‘burned in’, leading to the selection of cells endowed with a transcriptional drug resistance and thus more chemoresistant cancers.

Sydney M. Shaffer
Margaret C. Dunagin
Arjun Raj
Research15 Jun 2017
Nature

Volume: 546, P: 431-435

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Correction: Corrigendum: Rare cell variability and drug-induced reprogramming as a mode of cancer drug resistance

CTCF blocks antisense transcription initiation at divergent promoters

Diverse clonal fates emerge upon drug treatment of homogeneous cancer cells

LADL: light-activated dynamic looping for endogenous gene expression control

Tumor-associated B-cells induce tumor heterogeneity and therapy resistance

Single-cell differences in matrix gene expression do not predict matrix deposition

ClampFISH detects individual nucleic acid molecules using click chemistry–based amplification

The long non-coding RNA Morrbid regulates Bim and short-lived myeloid cell lifespan

Rare cell variability and drug-induced reprogramming as a mode of cancer drug resistance

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