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Showing 1–3 of 3 results

Advanced filters: Author: Margaret M. Fettis Clear advanced filters

Suppression of local inflammation via galectin-anchored indoleamine 2,3-dioxygenase

An anti-inflammatory enzyme fused with a tissue-anchoring protein and injected into inflamed tissues ameliorates local inflammation without causing systemic immune suppression, as shown in multiple rodent models of inflammatory diseases.

Evelyn Bracho-Sanchez
Fernanda G. Rocha
Benjamin G. Keselowsky
ResearchOpen Access01 May 2023
Nature Biomedical Engineering

Volume: 7, P: 1156-1169
Intracellular immune sensing promotes inflammation via gasdermin D–driven release of a lectin alarmin

Damage-associated molecular patterns (DAMPs) are released during necrotic cell death and contribute to driving inflammation. Rathinam and colleagues show that galectin-1 is a new DAMP that functions by inhibiting the receptor phosphatase CD45.

Ashley J. Russo
Swathy O. Vasudevan
Vijay A. Rathinam
Research04 Jan 2021
Nature Immunology

Volume: 22, P: 154-165
Locally anchoring enzymes to tissues via extracellular glycan recognition

The use of enzymes as drugs requires that they persist within target tissues over therapeutically relevant time frames. Here the authors use a galectin-3 fusion to anchor enzymes at injection sites for up to 14 days.

Shaheen A. Farhadi
Evelyn Bracho-Sanchez
Gregory A. Hudalla
ResearchOpen Access22 Nov 2018
Nature Communications

Volume: 9, P: 1-14