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Showing 1–3 of 3 results
Advanced filters: Author: Margarida Archer Clear advanced filters

  • Here, the authors present cryoEM structures of AftB, a key mycobacterial enzyme that adds terminal arabinose residues to the cell wall. In concert with functional assays and MD simulations, mechanistic insights are presented.

    • Yaqi Liu
    • Chelsea M. Brown
    • Filippo Mancia
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16

  • The CDP-alcohol phosphatidyltransferase family is involved in phospholipid biosynthesis. Here, Nogly et al.report the crystal structure of a bifunctional enzyme from this family, show that magnesium is required for enzymatic activity, and propose a structure-based catalytic mechanism.

    • Przemyslaw Nogly
    • Ivan Gushchin
    • Margarida Archer
    Research
    Nature Communications
    Volume: 5, P: 1-10

  • The cryo-EM structure of Mycobacterium smegmatis arabinosyltransferase B EmbB involved in mycobacterial cell wall biosynthesis provides insights into the substrate binding and reaction mechanism. Mapping of the ethambutol resistance associated mutations onto the structure suggests the location of the drug binding site.

    • Yong Zi Tan
    • José Rodrigues
    • Filippo Mancia
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-10