Proudfoot, Gullerova and colleagues show that mammalian Dicer localizes to the nucleus, where its levels are tightly regulated. Dicer interacts with RNA polymerase II and seems to restrict double-stranded (ds) RNA formation from convergent transcription. Dicer knockdown leads to accumulation of dsRNA, triggering the interferon response pathway and cellular apoptosis.
- Eleanor White
- Margarita Schlackow
- Monika Gullerova
