Repulsive guidance molecule-a (RGMa) is an axon guidance molecule that is involved in retinal development and neural tube closure. Toshihide Yamashita and colleagues describe a previously unrecognized role for RGMa in the immune system. Blockade of RGMa attenuates clinical symptoms of experimental autoimmune encephalomyelitis and reduces T cell proliferation and cytokine release. These results suggest a possible new therapeutic target for multiple sclerosis.
- Rieko Muramatsu
- Takekazu Kubo
- Toshihide Yamashita
