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Showing 1–6 of 6 results
Advanced filters: Author: Maria A Christophorou Clear advanced filters

  • Here the authors leverage state-of-the-art quantitative proteomics to provide a comprehensive overview of the human citrullinome. Supporting evidence from peptide microarrays hints at the potential clinical relevance of some of the identified sites.

    • Alexandra S. Rebak
    • Ivo A. Hendriks
    • Michael L. Nielsen
    ResearchOpen Access
    Nature Structural & Molecular Biology
    Volume: 31, P: 977-995

  • MYC activation can sensitise cells to apoptosis upon glutamine withdrawal. Here the authors show that MYC activation enhances global transcription and translation that creates a metabolic demand, while glutamine limitation causes a metabolic demand and supply imbalance through loss of TCA energetics and thus, sensitises cells to apoptosis.

    • Joy Edwards-Hicks
    • Huizhong Su
    • Andrew J. Finch
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-16

  • This study shows that PADI4-mediated citrullination occurs during pluripotency and that citrullination of H1 results in loosening of chromatin compaction; furthermore, citrullination is shown to be important for the activation of stem-cell genes, for iPS cell reprogramming and to maintain pluripotent cells in the early mouse embryo.

    • Maria A. Christophorou
    • Gonçalo Castelo-Branco
    • Tony Kouzarides
    Research
    Nature
    Volume: 507, P: 104-108

  • As fruitfly epithelial cells round up during mitosis, tricellular junctions serve as spatial landmarks, encoding information about interphase cell shape directionality to orient mitosis, and promoting geometric and mechanical sensing in epithelial tissues.

    • Floris Bosveld
    • Olga Markova
    • Yohanns Bellaïche
    Research
    Nature
    Volume: 530, P: 495-498