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Showing 1–11 of 11 results
Advanced filters: Author: Maria Carmo-Fonseca Clear advanced filters

  • The efficiency of somatic cell reprogramming is lowered by ageing. Here the authors show that the transcription factor Zeb2 and its long non-coding RNA Zeb2-NAT are expressed at high levels in older fibroblasts and their inhibition increases reprogramming efficiency.

    • Bruno Bernardes de Jesus
    • Sérgio Pires Marinho
    • Maria Carmo-Fonseca
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-11

  • The interior of the eukaryotic cell nucleus is populated by a multitude of microscopic domains termed nuclear bodies. Despite having attracted much attention, how these compartments form and are maintained remained elusive. Now, two live-cell imaging studies provide compelling evidence that nascent RNAs can act as transiently immobilized scaffolds that recruit specific nuclear body proteins.

    • Maria Carmo-Fonseca
    • José Rino
    News & Views
    Nature Cell Biology
    Volume: 13, P: 110-112

  • DNMT3A is best known for its de novo DNA methyltransferase activity. But a new study shows that the protein also has a role in RNA splicing during activation of embryonic and haematopoietic stem cells. This introduces a new perspective for approaching diseases associated with DNMT3A mutations.

    • Maria Carmo-Fonseca
    News & Views
    Nature Cell Biology
    Volume: 25, P: 516-517

  • Chromatin has been implicated in splicing regulation, but whether a causal relationship exists between pre-mRNA splicing and histone modification has been unclear. New genome-wide analyses now show that pre-mRNA splicing influences H3K36 trimethylation, and that splicing inhibition impairs the recruitment of H3K36 methyltransferase HYPB/Setd2, while splicing activation has the opposite effect.

    • Sérgio Fernandes de Almeida
    • Ana Rita Grosso
    • Maria Carmo-Fonseca
    Research
    Nature Structural & Molecular Biology
    Volume: 18, P: 977-983

  • Post-transcriptional maturation of pre-mRNAs involves a number of processes that are now known to interact with transcription itself. Mutations affecting early spliceosome assembly, but not a drug targeting a catalytic step of splicing, are now shown to lead to nascent transcript retention and pausing of RNA polymerase II predominantly at the 3′ end of the gene, suggesting cross-talk between splicing and transcriptional termination.

    • Sandra Bento Martins
    • José Rino
    • Maria Carmo-Fonseca
    Research
    Nature Structural & Molecular Biology
    Volume: 18, P: 1115-1123

  • XPA-binding protein (XAB)-2 is the human homologue of the yeast pre-mRNA splicing factor Syf1. Here the authors use an in vivo biotinylation tagging approach to show XAB2’s role in DNA repair, RNA splicing and transcription during mammalian development.

    • Evi Goulielmaki
    • Maria Tsekrekou
    • George A. Garinis
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-19

  • Precursor mRNA processing, which includes the removal of introns by splicing and the formation of 3′ ends by cleavage and polyadenylation, is frequently altered in tumours. This Review describes small molecules and oligonucleotides that modulate the spliceosome and are now in clinical trials for the treatment of cancer.

    • Joana Desterro
    • Pedro Bak-Gordon
    • Maria Carmo-Fonseca
    Reviews
    Nature Reviews Drug Discovery
    Volume: 19, P: 112-129

  • Alternative splicing determines which exons are included in mature RNA and accounts for the majority of transcriptomic diversity. In this Review, Gotthardt and colleagues discuss how alternative splicing is regulated in the heart and how it differs in cardiac development, physiological adaptation and pathological remodelling. They also summarize technological advances in the field and potential applications of splicing data in cardiovascular medicine.

    • Michael Gotthardt
    • Victor Badillo-Lisakowski
    • Leslie Leinwand
    Reviews
    Nature Reviews Cardiology
    Volume: 20, P: 517-530