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Showing 1–3 of 3 results
Advanced filters: Author: Maria Claudia Peroto Clear advanced filters

  • Time-resolved cryo-electron microscopy of the μ-opioid receptor bound to various ligands enables a detailed look at the mechanisms that underlie GTP-induced activation of G proteins, and how different ligands affect activation kinetics.

    • Michael J. Robertson
    • Arnab Modak
    • Georgios Skiniotis
    Research
    Nature
    P: 1-9

  • Cryo-EM has facilitated structural studies of membrane proteins, but inactive GPCRs have remained inaccessible due to their small size. Robertson et al. demonstrate a common nanobody-based approach to streamline the determination of such structures.

    • Michael J. Robertson
    • Makaía M. Papasergi-Scott
    • Georgios Skiniotis
    Research
    Nature Structural & Molecular Biology
    Volume: 29, P: 1188-1195

  • Cryo-electron microscopy structures of GPR56 and latrophilin 3 show how the released tethered agonist peptide interacts with the transmembrane domain, suggesting a model for the activation mechanism of adhesion G-protein-coupled receptors.

    • Ximena Barros-Álvarez
    • Robert M. Nwokonko
    • Georgios Skiniotis
    Research
    Nature
    Volume: 604, P: 757-762