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Showing 1–5 of 5 results
Advanced filters: Author: Maria E. Valieva Clear advanced filters

  • MYCN amplification is common in neuroblastomas. Here the authors analyse the MYCN amplicon structure and its epigenetic regulation by integrating short- and longread genomic and epigenomic data and find two classes of MYCN amplicons in neuroblastomas, one driven by local enhancers and the other by hijacking of distal regulatory elements.

    • Konstantin Helmsauer
    • Maria E. Valieva
    • Richard P. Koche
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-12

  • Extrachromosomal DNA (ecDNA) congregates in clusters called ecDNA hubs that promote intermolecular interactions between gene-regulatory regions and thereby amplify the expression of oncogenes such as MYC in cancer cell lines.

    • King L. Hung
    • Kathryn E. Yost
    • Howard Y. Chang
    Research
    Nature
    Volume: 600, P: 731-736

  • Curaxins are a recently discovered class of anti-cancer agents that disturbs DNA/histone interactions within. Here the authors provide evidence that curaxins affect the spatial genome organization and compromise enhancer-promoter communication necessary for expression of several oncogenes, including MYC.

    • Omar L. Kantidze
    • Artem V. Luzhin
    • Sergey V. Razin
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-11

  • spFRET microscopy analysis reveals how FACT reversibly uncoils DNA from nucleosomes during remodeling, thus modulating DNA accessibility in vitro and in vivo.

    • Maria E Valieva
    • Grigoriy A Armeev
    • Alexey V Feofanov
    Research
    Nature Structural & Molecular Biology
    Volume: 23, P: 1111-1116

  • Sivkina et al. present a biochemical and biophysical characterization of the interaction of S. cerevisiae histone chaperone FACT with the nucleosome core particle. They show that FACT adopts a more open geometry in the presence of Nhp6, and together they unfold nucleosomes to an almost extended conformation, suggesting a mechanism for FACT-facilitated disassembly of nucleosomes.

    • Anastasiia L. Sivkina
    • Maria G. Karlova
    • Vasily M. Studitsky
    ResearchOpen Access
    Communications Biology
    Volume: 5, P: 1-9