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Showing 1–5 of 5 results
Advanced filters: Author: Maria Firulyova Clear advanced filters
  • Patterson, Firulyova, et al. report that TREM2 is a key regulator of foamy macrophage differentiation. Myeloid-specific deletion of Trem2 caused increased macrophage susceptibility to cholesterol-mediated toxicity and cell death and significantly attenuated atherosclerotic plaque progression in mice.

    • Michael T. Patterson
    • Maria M. Firulyova
    • Jesse W. Williams
    ResearchOpen Access
    Nature Cardiovascular Research
    Volume: 2, P: 1015-1031
  • Adipose tissue is composed of a number of adipocytes and a number of other cells including immune cells. Here the authors use single-cell sequencing of murine brown adipose tissue immune cells and describe multiple macrophage and monocyte subsets and show that monocytes contribute to brown adipose tissue expansion.

    • Alexandre Gallerand
    • Marion I. Stunault
    • Stoyan Ivanov
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-13
  • A study finds T cells in areas of tau, not amyloid, pathology in Alzheimer’s disease brain and mouse models, with their presence correlating with neuronal loss and their depletion, or that of microglia, preventing neurodegeneration and cognitive decline.

    • Xiaoying Chen
    • Maria Firulyova
    • David M. Holtzman
    Research
    Nature
    Volume: 615, P: 668-677