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Showing 1–5 of 5 results
Advanced filters: Author: Maria Nemethova Clear advanced filters

  • Complex genomic alterations segregate melanoma into different molecular subsets, but for most subsets it is unclear whether they drive a distinct clinical behaviour. Here, the authors use gene-expression data from melanoma patients to search for outlier genes that correlate with survival and identify that MTSS1 is associated with metastasis.

    • Kirsten D. Mertz
    • Gaurav Pathria
    • Stephan N. Wagner
    Research
    Nature Communications
    Volume: 5, P: 1-11

  • Electron tomography provides unprecedented three-dimensional images of lamellipodial actin in frozen, ‘live’ cells. The vast majority of actin filaments at the leading edge are unbranched, requiring a re-examination of the role of Arp2/3-mediated branching in vivo.

    • Edit Urban
    • Sonja Jacob
    • J. Victor Small
    Research
    Nature Cell Biology
    Volume: 12, P: 429-435

  • Postoperative ileus is a common complication of abdominal surgery and places a considerable burden on health-care systems. In this Review, the authors outline evidence that postoperative ileus is mediated by the immune system and highlight new therapeutic approaches to interrupt the inflammatory cascade that characterizes this condition.

    • Sjoerd H. W. van Bree
    • Andrea Nemethova
    • Guy E. Boeckxstaens
    Reviews
    Nature Reviews Gastroenterology & Hepatology
    Volume: 9, P: 675-683

  • A new protein, Arpin, is identified that inhibits the Arp2/3 complex and controls cell migration by decreasing cell speed and the directional persistence of migration; this inhibitory circuit is under the control of the small GTPase Rac1, and Arpin depletion causes faster lamellipodia protrusion and increased cell migration.

    • Irene Dang
    • Roman Gorelik
    • Alexis Gautreau
    Research
    Nature
    Volume: 503, P: 281-284