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Showing 1–6 of 6 results

Advanced filters: Author: Maria Pokrovskii Clear advanced filters

PRDM16-dependent antigen-presenting cells induce tolerance to gut antigens

A subset of antigen-presenting cells of myeloid origin that require PRDM16 and RORγt regulates T cell function to enable immune tolerance of food and commensal gut microorganisms.

Liuhui Fu
Rabi Upadhyay
Dan R. Littman
ResearchOpen Access14 Apr 2025
Nature

Volume: 642, P: 756-765
Author Correction: c-MAF-dependent regulatory T cells mediate immunological tolerance to a gut pathobiont

Mo Xu
Maria Pokrovskii
Dan R. Littman
Amendments and Corrections05 Feb 2019
Nature

Volume: 566, P: E7
A RORγt⁺ cell instructs gut microbiota-specific T_reg cell differentiation

Induction of T regulatory cells by gut microbes is mediated by antigen-presenting RORγt⁺ cells, unlike that of T follicular helper and T helper 17 cells, which requires different cell types.

Ranit Kedmi
Tariq A. Najar
Dan R. Littman
Research07 Sept 2022
Nature

Volume: 610, P: 737-743
c-MAF-dependent regulatory T cells mediate immunological tolerance to a gut pathobiont

The transcription factor c-MAF is required for the generation of Helicobacter-specific regulatory T cells that selectively restrain pro-inflammatory T_H17 cells; the absence of c-MAF in mouse regulatory T cells results in pathobiont-dependent inflammatory bowel disease.

Mo Xu
Maria Pokrovskii
Dan R. Littman
Research07 Feb 2018
Nature

Volume: 554, P: 373-377
Publisher Correction: A RORγt⁺ cell instructs gut microbiota-specific T_reg cell differentiation

Ranit Kedmi
Tariq A. Najar
Dan R. Littman
Amendments and Corrections23 Sept 2022
Nature

Volume: 610, P: E7
Critical role of IRF1 and BATF in forming chromatin landscape during type 1 regulatory cell differentiation

Tr1 cells have potent regulatory effects in vitro and in vivo. Kuchroo and colleagues comprehensively describe the epigenetic, transcriptional and gene regulatory landscape that is essential for Tr1 cell differentiation.

Katarzyna Karwacz
Emily R Miraldi
Vijay K Kuchroo
Research06 Feb 2017
Nature Immunology

Volume: 18, P: 412-421