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Showing 1–2 of 2 results
Advanced filters: Author: Maria Pouyiourou Clear advanced filters
  • Cancer of unknown primary (CUP) constitutes a diagnostic quandary and has a dismal prognosis, with standard empirical chemotherapy providing limited benefit. This Review outlines diagnostic innovations that are improving tissue-of-origin prediction as well as novel treatment strategies that have shown promise for improving outcomes in patients with CUP.

    • Maria Pouyiourou
    • Tilmann Bochtler
    • Alwin Krämer
    Reviews
    Nature Reviews Clinical Oncology
    Volume: 22, P: 781-799
  • Standard of care for unfavorable-risk cancer of unknown primary (CUP) comprises platinum-based chemotherapy as first-line treatment, however therapeutic options remain limited. Here the authors report the results of a phase II trial of combined nivolumab (anti-PD1) and ipilimumab (anti-CTLA4) in patients with unfavorable CUP.

    • Maria Pouyiourou
    • Bianca N. Kraft
    • Alwin Krämer
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-21