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Showing 1–5 of 5 results

Advanced filters: Author: Maria Stella Ritorto Clear advanced filters

Screening of DUB activity and specificity by MALDI-TOF mass spectrometry

Deubiquitylases (DUBs) remove ubiquitin chains from proteins. Here the authors develop a mass spectrometry-based DUB activity screen using unmodified diubiquitin isomers to characterize substrate specificity for 42 human DUBs, and assess the potency and selectivity of 11 DUB inhibitors.

Maria Stella Ritorto
Richard Ewan
Matthias Trost
ResearchOpen Access27 Aug 2014
Nature Communications

Volume: 5, P: 1-11
High-throughput matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry–based deubiquitylating enzyme assay for drug discovery

The authors describe a protocol for a high-throughput version of the MALDI-TOF–based deubiquitylating enzyme assay method.

Virginia De Cesare
Jennifer Moran
Paul Davies
Protocols02 Nov 2020
Nature Protocols

Volume: 15, P: 4034-4057
Inhibition of USP10 induces degradation of oncogenic FLT3

An inhibitor of the deubiquitinase (DUB) USP10 regulates the degradation of oncogenic FLT3, thus defining USP10 as a DUB for FLT3 and providing a therapeutic approach for human acute myeloid leukemia in which FLT3 activation is dysregulated.

Ellen L Weisberg
Nathan J Schauer
Sara J Buhrlage
Research02 Oct 2017
Nature Chemical Biology

Volume: 13, P: 1207-1215
USP7 small-molecule inhibitors interfere with ubiquitin binding

The development of selective ubiquitin-specific protease-7 (USP7) inhibitors GNE-6640 and GNE-6776, which induce tumour cell death and reveal differential kinetics of Lys-48 and Lys-63-linked ubiquitin chain depolymerization by USP7.

Lorna Kategaya
Paola Di Lello
Ingrid E. Wertz
Research18 Oct 2017
Nature

Volume: 550, P: 534-538
Dimethyl fumarate blocks pro-inflammatory cytokine production via inhibition of TLR induced M1 and K63 ubiquitin chain formation

Victoria A. McGuire
Tamara Ruiz-Zorrilla Diez
J. Simon C. Arthur
ResearchOpen Access08 Aug 2016
Scientific Reports

Volume: 6, P: 1-17