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Showing 1–4 of 4 results
Advanced filters: Author: Maria Thanasoula Clear advanced filters

  • Mutations in BRCA2 are associated with higher susceptibility to some forms of cancer. BRCA2 is known to play a central role in the repair of DNA breaks via homologous recombination. Now a role for BRCA2 in telomere integrity is revealed, indicating that BRCA2 can contribute to genome stability in multiple ways.

    • Sophie Badie
    • Jose M Escandell
    • Madalena Tarsounas
    Research
    Nature Structural & Molecular Biology
    Volume: 17, P: 1461-1469

  • A transposon mutagenesis screen indicates that loss of 53BP1 expression rescues the clonal growth defect of BRCA1 null cells. 53BP1 deficiency is shown to abrogate the cell cycle arrest triggered in the absence of BRCA1 and to partially restore homologous recombination. The potential clinical implications of these findings are supported by the reduction of 53BP1 expression in sporadic triple-negative and BRCA-associated breast cancers.

    • Peter Bouwman
    • Amal Aly
    • Jos Jonkers
    Research
    Nature Structural & Molecular Biology
    Volume: 17, P: 688-695

  • The near-complete in vitro reconstitution of the mitotic spindle assembly checkpoint reveals how the assembly of its effector, the mitotic checkpoint complex, is catalysed.

    • Alex C. Faesen
    • Maria Thanasoula
    • Andrea Musacchio
    Research
    Nature
    Volume: 542, P: 498-502