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Designing antifilarial drug trials using clinical trial simulators

Drugs for filariases are under development and clinical trial simulators could help to inform the design of clinical trials. Here, Walker et al. use an individual-based onchocerciasis transmission model to project trial outcomes of a hypothetical macrofilaricidal drug, resolving key design choices.

Martin Walker
Jonathan I. D. Hamley
Maria-Gloria Basáñez
ResearchOpen Access01 Jun 2020
Nature Communications

Volume: 11, P: 1-11
Modelling onchocerciasis-associated epilepsy and the impact of ivermectin treatment on its prevalence and incidence

Onchocerciasis is a vector-borne disease endemic to parts of sub-Saharan Africa and associated with substantial morbidity including reports of onchocerciasis-associated epilepsy. Here, the authors use mathematical modelling to assess the impact of community-directed treatment with ivermectin on onchocerciasis-associated epilepsy.

Jacob N. Stapley
Jonathan I. D. Hamley
Maria-Gloria Basáñez
ResearchOpen Access25 Jul 2024
Nature Communications

Volume: 15, P: 1-11
Antibiotics in ingested human blood affect the mosquito microbiota and capacity to transmit malaria

The gut microbiota of malaria-transmitting mosquitoes contributes to the insects’ resistance to the parasite. Here, Gendrin et al. show that antibiotics in ingested human blood alter the mosquito gut microbiota and increase the insect’s survival, fecundity and susceptibility to the parasites.

Mathilde Gendrin
Faye H. Rodgers
George K. Christophides
ResearchOpen Access06 Jan 2015
Nature Communications

Volume: 6, P: 1-7
Force-of-infection of Taenia solium porcine cysticercosis: a modelling analysis to assess global incidence and prevalence trends

Matthew A. Dixon
Peter Winskill
Maria-Gloria Basáñez
ResearchOpen Access19 Oct 2020
Scientific Reports

Volume: 10, P: 1-14

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Designing antifilarial drug trials using clinical trial simulators

Modelling onchocerciasis-associated epilepsy and the impact of ivermectin treatment on its prevalence and incidence

Antibiotics in ingested human blood affect the mosquito microbiota and capacity to transmit malaria

Force-of-infection of Taenia solium porcine cysticercosis: a modelling analysis to assess global incidence and prevalence trends

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