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Nature Biomedical Engineering (1)

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Interleukin-31-mediated photoablation of pruritogenic epidermal neurons reduces itch-associated behaviours in mice

A photosensitizer-tagged derivative of the interleukin-31 ligand that mediates the photoablation of itch-sensing skin neurons expressing the corresponding interleukin receptor reverses scratching behaviour of mice with atopic dermatitis.

Linda Nocchi
Nainika Roy
Paul A. Heppenstall
Research17 Dec 2018
Nature Biomedical Engineering

Volume: 3, P: 114-125

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Interleukin-31-mediated photoablation of pruritogenic epidermal neurons reduces itch-associated behaviours in mice

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