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Crystal structures of the catalytic domain of human protein kinase associated with apoptosis and tumor suppression

Valentina Tereshko
Marianna Teplova
Martin Egli
Research01 Oct 2001
Nature Structural Biology

Volume: 8, P: 899-907
Recognition of distinct RNA motifs by the clustered CCCH zinc fingers of neuronal protein Unkempt

A new crystal structure of mouse Unkempt, a translational regulator of neuronal cell morphology, reveals how its two zinc-finger-triplet clusters recognize distinct cognate RNA sites.

Jernej Murn
Marianna Teplova
Dinshaw J Patel
Research07 Dec 2015
Nature Structural & Molecular Biology

Volume: 23, P: 16-23
Crystal structure and improved antisense properties of 2'-O-(2-methoxyethyl)-RNA

Marianna Teplova
George Minasov
Martin Egli
Research01 Jun 1999
Nature Structural Biology

Volume: 6, P: 535-539
Structural insights into RNA recognition by the alternative-splicing regulator muscleblind-like MBNL1

Muscleblind-like (MBNL) proteins have been implicated in alternative-splicing regulation during development, and altered levels of these proteins have been implicated in myotonic dystrophy. The structure of the MBNL1 zinc finger domains in complex with RNA indicates how the target sequence is recognized and suggests that an antiparallel arrangement of the zinc fingers causes a trajectory reversal in the pre-mRNA target. The potential role of such generated looped segments in alternative splicing is discussed.

Marianna Teplova
Dinshaw J Patel
Research30 Nov 2008
Nature Structural & Molecular Biology

Volume: 15, P: 1343-1351
Structure-based insights into self-cleavage by a four-way junctional twister-sister ribozyme

Twister-sister is a self-cleaving ribozyme. Here, the authors report the 2.0 Å crystal structure of the four-way junctional twister-sister ribozyme in the pre-catalytic state and discuss mechanistic implications based on their mutagenesis experiments and comparisons with other ribozyme structures.

Luqian Zheng
Elisabeth Mairhofer
Aiming Ren
ResearchOpen Access30 Oct 2017
Nature Communications

Volume: 8, P: 1-12
Structure-function studies of nucleocytoplasmic transport of retroviral genomic RNA by mRNA export factor TAP

The TAP-p15 heterodimer is involved in nuclear export of messenger RNAs. The crystal structure of TAP (RRM + LRR domains) bound to part of the export element found in simian type D retroviral RNAs, together with analysis of mutants in export assays, now provides insight into how this element is recognized and exploits the host nuclear transport system.

Marianna Teplova
Lara Wohlbold
Dinshaw J Patel
Research07 Aug 2011
Nature Structural & Molecular Biology

Volume: 18, P: 990-998

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Crystal structures of the catalytic domain of human protein kinase associated with apoptosis and tumor suppression

Recognition of distinct RNA motifs by the clustered CCCH zinc fingers of neuronal protein Unkempt

Crystal structure and improved antisense properties of 2'-O-(2-methoxyethyl)-RNA

Structural insights into RNA recognition by the alternative-splicing regulator muscleblind-like MBNL1

Structure-based insights into self-cleavage by a four-way junctional twister-sister ribozyme

Structure-function studies of nucleocytoplasmic transport of retroviral genomic RNA by mRNA export factor TAP

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