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Showing 1–2 of 2 results
Advanced filters: Author: Marianne Delville Clear advanced filters

  • FOXP3 deficiency leads to dramatic loss of immune homeostasis. This multicenter collaborative group finds that loss of FOXP3 function only disrupts a few core genes, but this unmasks a degree of systemic inflammation, and it is this environment that then strongly perturbs Treg cells.

    • David Zemmour
    • Louis-Marie Charbonnier
    • Christophe Benoist
    Research
    Nature Immunology
    Volume: 22, P: 607-619

  • Chimeric antigen receptor engineering in T cells has been shown to be of great potential therapeutic benefit in a range of immune pathologies, although the functionality of such cell therapies can be limited due to tonic signalling and the induction of dysfunction. Here the authors show transient inhibition of mTOR can rescue their 41-BB-CAR-Tregs from tonic signalling-induced dysfunction.

    • Baptiste Lamarthée
    • Armance Marchal
    • Julien Zuber
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-19