Stephane Schurmans and colleagues show that mice lacking the enzyme inositol polyphosphate-5-phosphatase E (Inpp5e) develop a multiorgan disorder with defects in primary cilia. They also report a mutation in human INPP5E in a family with MORM syndrome, a condition similar to Bardet-Biedl syndrome.
- Monique Jacoby
- James J Cox
- Stéphane Schurmans
