Autoimmune encephalitis (AIE) may involve neuron-specific cytotoxic T cells, but evidence is still lacking. Here the authors use induced pluripotent stem cells from patients with AIE and single cell RNA-sequencing of ex vivo CD8 T cells to find neuron-specific, KIR+CD8+ T cells with altered transcriptome that potentially contribute to AIE etiology.
- Sylvain Perriot
- Samuel Jones
- Renaud Du Pasquier
