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Showing 1–4 of 4 results
Advanced filters: Author: Marie Tollot Clear advanced filters

  • Immune system function declines with age, a consequence of defects in hematopoietic stem cells (HSCs). Here the authors show that TAZ buffers age-related loss of PU.1 activity to maintain HSC functionality and identify the surface protein Clca3a1 as a marker of “young-like” HSCs, even in old mice.

    • Kyung Mok Kim
    • Anna Mura-Meszaros
    • Björn von Eyss
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-16

  • YAP is a transcriptional co-activator downstream of Hippo pathway that displays oncogenic but also tumour suppressive functions. Here, the authors perform an unbiased genome wide CRISPR screen and identify Trichorhinophalangeal syndrome 1 (TRPS1) that represses YAP/TEAD activity independently of Hippo pathway in breast cancer.

    • Dana Elster
    • Marie Tollot
    • Björn von Eyss
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-16

  • Biotrophic fungal plant pathogens secrete protein effectors that support colonization of the host. Here, Kahmann and colleagues discuss new insights into the effector repertoire of smut fungi, the molecular mechanisms whereby effectors ofUstilago maydischange plant cell processes, how the respective genes are regulated and how effectors evolve.

    • Daniel Lanver
    • Marie Tollot
    • Regine Kahmann
    Reviews
    Nature Reviews Microbiology
    Volume: 15, P: 409-421