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Showing 1–4 of 4 results
Advanced filters: Author: Marie-Gabrielle Duperron Clear advanced filters

  • Genomic analyses of large population-based cohorts uncover the genetic determinants of perivascular space burden, an MRI marker of cerebral small vessel disease, across the lifespan, and reveal potential pathways implicated in the etiology of stroke and dementia.

    • Marie-Gabrielle Duperron
    • Maria J. Knol
    • Stéphanie Debette
    ResearchOpen Access
    Nature Medicine
    Volume: 29, P: 950-962

  • By integrating large-scale genomic and proteomic data in cerebrospinal fluid and plasma, the authors identify 49 proteins linked to MRI markers of cerebral small vessel disease, highlighting extracellular matrix and immune pathways, with biomarker and therapeutic potential.

    • Ilana Caro
    • Daniel Western
    • Stéphanie Debette
    ResearchOpen Access
    Nature Aging
    Volume: 5, P: 2514-2531

  • White matter hyperintensities (WMH) are a common brain-imaging feature of cerebral small vessel disease. Here, the authors carry out a GWAS and followup analyses for WMH-volume, implicating several variants with potential for risk stratification and drug targeting.

    • Muralidharan Sargurupremraj
    • Hideaki Suzuki
    • Stéphanie Debette
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-18

  • Meta-analysis of genome-wide association studies on Alzheimer’s disease and related dementias identifies new loci and enables generation of a new genetic risk score associated with the risk of future Alzheimer’s disease and dementia.

    • Céline Bellenguez
    • Fahri Küçükali
    • Jean-Charles Lambert
    ResearchOpen Access
    Nature Genetics
    Volume: 54, P: 412-436