Nature Search

Concordance of HER2-low scoring in breast carcinomas among pathologists

Snježana Tomić
Tatjana Kapicl Ivković
Toni Čeprnja
ResearchOpen Access09 Jul 2025
Scientific Reports

Volume: 15, P: 1-8
Cryo-EM analyses unveil details of mechanism and targocil-II mediated inhibition of S. aureus WTA transporter TarGH

Cryo-EM illuminates atomic binding details and far-ranging conformational effects of the inhibitor targocil-II on wall teichoic acid ABC transporter TarGH, a virulence target from the antibiotic resistant, often hospital acquired pathogen S. aureus.

Franco K. K. Li
Shaun C. Peters
Natalie C. J. Strynadka
ResearchOpen Access04 Apr 2025
Nature Communications

Volume: 16, P: 1-14
Cryo-EM characterization of the anydromuropeptide permease AmpG central to bacterial fitness and β-lactam antibiotic resistance

AmpG is an MFS importer of bacterial cell wall fragments. Here, authors present a cryoEM structure and supporting mutagenesis to illuminate AmpG’s essential role in bacterial fitness and derepression of broad-spectrum β-lactam antibiotic resistance.

Helena E. Sverak
Luke N. Yaeger
Natalie CJ Strynadka
ResearchOpen Access16 Nov 2024
Nature Communications

Volume: 15, P: 1-16
Profiling and genetic control of the murine immunoglobulin G glycome

Comprehensive glycome profiling of immunoglobulin G (IgG) in 95 strains of mice from the Collaborative Cross genetics resource reveals the extent and variability of IgG glycosylation in vivo.

Jasminka Krištić
Olga O. Zaytseva
Gordan Lauc
Research09 Apr 2018
Nature Chemical Biology

Volume: 14, P: 516-524
Structural characterization of the molecular platform for type III secretion system assembly

Calvin K. Yip
Tyler G. Kimbrough
Natalie C. J. Strynadka
Research02 Jun 2005
Nature

Volume: 435, P: 702-707
Structural analysis of the essential self-cleaving type III secretion proteins EscU and SpaS

A type II β-turn in the Escherichia coli protein EscU undergoes auto-cleavage via a mechanism involving cyclization of a conserved asparagine residue. Structural and in vivo analysis of point and deletion mutations illustrates the subtle conformational effects of auto-cleavage in modulating the molecular features of a highly conserved surface region of EscU, a potential point of interaction with other T3SS components at the inner membrane.

Raz Zarivach
Wanyin Deng
Natalie C. J. Strynadka
Research01 May 2008
Nature

Volume: 453, P: 124-127
Emergence of superconductivity in the cuprates via a universal percolation process

The emergence of superconductivity from the normal state in the cuprates above the transition temperature (T_c) has been controversial. Here, Pelc et al. report nonlinear conductivity, resulting from superconducting precursors only, vanishing exponentially above T_c both with temperature and with magnetic field.

Damjan Pelc
Marija Vučković
Neven Barišić
ResearchOpen Access18 Oct 2018
Nature Communications

Volume: 9, P: 1-10
X-ray crystallographic characterization of the SARS-CoV-2 main protease polyprotein cleavage sites essential for viral processing and maturation

The SARS-CoV-2 protease Mpro is essential for viral replication. Here, the authors have determined the structures of Mpro in complex with 10 of the 11 viral cleavage sequences including a covalent acyl-enzyme intermediate, providing mechanistic and structural insights for antiviral development.

Jaeyong Lee
Calem Kenward
Mark Paetzel
ResearchOpen Access03 Sept 2022
Nature Communications

Volume: 13, P: 1-13
Structural basis of broad-spectrum β-lactam resistance in Staphylococcus aureus

Cryo-electron microscopy structures of Staphylococcus aureus BlaR1 reveal dynamic signalling states regulating broad spectrum β-lactam antibiotic resistance through cleavage of the transcriptional repressor BlaI and induced expression of the β-lactamase blaZ and the β-lactam-resistant cell-wall transpeptidase mecA.

J. Andrew N. Alexander
Liam J. Worrall
Natalie C. J. Strynadka
ResearchOpen Access04 Jan 2023
Nature

Volume: 613, P: 375-382
Crystallographic structure of wild-type SARS-CoV-2 main protease acyl-enzyme intermediate with physiological C-terminal autoprocessing site

The SARS-CoV-2 main protease (M^pro) is one of two cysteine proteases essential for viral replication. Here, the authors determine the crystal structure of an M^pro acyl intermediate with its native C-terminal autocleavage sequence and the structure of a product bound active site mutant (C145A), which are of interest for antiviral drug development.

Jaeyong Lee
Liam J. Worrall
Natalie C. J. Strynadka
ResearchOpen Access18 Nov 2020
Nature Communications

Volume: 11, P: 1-9
Cryo-EM structure of the homohexameric T3SS ATPase-central stalk complex reveals rotary ATPase-like asymmetry

Many Gram-negative bacteria rely on a type III secretion system (T3SS) for their pathogenicity. Here authors present the cryo-EM structure of the E.coli T3SS ATPase-central stalk complex, which forms a homohexameric, asymmetric pore with different functional states.

Dorothy D. Majewski
Liam J. Worrall
Natalie C. J. Strynadka
ResearchOpen Access07 Feb 2019
Nature Communications

Volume: 10, P: 1-12
Structural insight into YcbB-mediated beta-lactam resistance in Escherichia coli

In E. coli, alternate peptidoglycan crosslinking reactions carried out by the L,D-transpeptidase YcbB can lead to beta-lactam resistance. Here, Caveney et al. solve the crystal structure of YcbB and shed light into its mechanism of action and into YcbB-mediated antibiotic resistance.

Nathanael A. Caveney
Guillermo Caballero
Natalie C. J. Strynadka
ResearchOpen Access23 Apr 2019
Nature Communications

Volume: 10, P: 1-11
T3S injectisome needle complex structures in four distinct states reveal the basis of membrane coupling and assembly

Cryo-EM imaging of the needle complex of the SPI-1 type III secretion system from Salmonella enterica serovar Typhimurium at different stages of complex assembly elucidates how needle assembly initiation is regulated and how the inner membrane and outer membrane rings of the complex interact, even with apparently incompatible symmetries.

Jinhong Hu
Liam J. Worrall
Natalie C. J. Strynadka
Research19 Aug 2019
Nature Microbiology

Volume: 4, P: 2010-2019
Structural analysis of a prototypical ATPase from the type III secretion system

Raz Zarivach
Marija Vuckovic
Natalie C J Strynadka
Research21 Jan 2007
Nature Structural & Molecular Biology

Volume: 14, P: 131-137
Genetic regulation of post-translational modification of two distinct proteins

Post-translational modifications are known to diversify protein functions, but the effect of genetic variation on the modifications is not well known. Here, the authors find both shared and protein-specific genetic mechanisms regulating the glycosylation of two different proteins.

Arianna Landini
Irena Trbojević-Akmačić
Lucija Klarić
ResearchOpen Access24 Mar 2022
Nature Communications

Volume: 13, P: 1-13
Effects of allergic diseases and age on the composition of serum IgG glycome in children

Marija Pezer
Jerko Stambuk
Gordan Lauc
ResearchOpen Access12 Sept 2016
Scientific Reports

Volume: 6, P: 1-10
A conserved structural motif mediates formation of the periplasmic rings in the type III secretion system

The type III secretion system (T3SS) of pathogenic bacteria is composed of a series of rings in the inner and outer bacterial membranes. Crystallographic studies of EscJ and PrgH, proteins that comprise the two inner membrane rings of the T3SS, suggest that a conserved structural motif serves as a platform for ring assembly. Additional docking and modeling studies reveal details of the T3SS architecture and assembly.

Thomas Spreter
Calvin K Yip
Natalie C J Strynadka
Research26 Apr 2009
Nature Structural & Molecular Biology

Volume: 16, P: 468-476
Trace N-glycans including sulphated species may originate from various plasma glycoproteins and not necessarily IgG

Gordan Lauc
Frano Vučković
Manfred Wuhrer
CorrespondenceOpen Access25 Jul 2018
Nature Communications

Volume: 9, P: 1-3
Integrative epigenome-wide analysis demonstrates that DNA methylation may mediate genetic risk in inflammatory bowel disease

Epigenetic perturbations may be an important factor in diseases where both genes and environment play a role. Here, Ventham and colleagues show that DNA methylation changes in inflammatory bowel disease are related to the underlying genotype, and are associated with cell-specific changes to gene expression.

N. T. Ventham
N. A. Kennedy
J. Satsangi
ResearchOpen Access25 Nov 2016
Nature Communications

Volume: 7, P: 1-14
Comparative analysis of transferrin and IgG N-glycosylation in two human populations

A large-scale comparative study in two human populations analyzes human plasma transferrin and immunoglobulin G (IgG) N-glycosylation profiles and their association with age, sex, and various biochemical and physiological traits.

Irena Trbojević-Akmačić
Frano Vučković
Gordan Lauc
ResearchOpen Access23 Mar 2023
Communications Biology

Volume: 6, P: 1-13
Interconnectedness between periodontitis stage, oral hygiene habits, adherence to the Mediterranean diet and nutritional status in Dalmatian kidney transplant recipients: a cross-sectional study

Josipa Radić
Marijana Vučković
Mislav Radić
ResearchOpen Access08 Jul 2022
Scientific Reports

Volume: 12, P: 1-11

Search

Concordance of HER2-low scoring in breast carcinomas among pathologists

Cryo-EM analyses unveil details of mechanism and targocil-II mediated inhibition of S. aureus WTA transporter TarGH

Cryo-EM characterization of the anydromuropeptide permease AmpG central to bacterial fitness and β-lactam antibiotic resistance

Profiling and genetic control of the murine immunoglobulin G glycome

Structural characterization of the molecular platform for type III secretion system assembly

Structural analysis of the essential self-cleaving type III secretion proteins EscU and SpaS

Emergence of superconductivity in the cuprates via a universal percolation process

X-ray crystallographic characterization of the SARS-CoV-2 main protease polyprotein cleavage sites essential for viral processing and maturation

Structural basis of broad-spectrum β-lactam resistance in Staphylococcus aureus

Crystallographic structure of wild-type SARS-CoV-2 main protease acyl-enzyme intermediate with physiological C-terminal autoprocessing site

Cryo-EM structure of the homohexameric T3SS ATPase-central stalk complex reveals rotary ATPase-like asymmetry

Structural insight into YcbB-mediated beta-lactam resistance in Escherichia coli

T3S injectisome needle complex structures in four distinct states reveal the basis of membrane coupling and assembly

Structural analysis of a prototypical ATPase from the type III secretion system

Genetic regulation of post-translational modification of two distinct proteins

Effects of allergic diseases and age on the composition of serum IgG glycome in children

A conserved structural motif mediates formation of the periplasmic rings in the type III secretion system

Trace N-glycans including sulphated species may originate from various plasma glycoproteins and not necessarily IgG

Integrative epigenome-wide analysis demonstrates that DNA methylation may mediate genetic risk in inflammatory bowel disease

Comparative analysis of transferrin and IgG N-glycosylation in two human populations

Interconnectedness between periodontitis stage, oral hygiene habits, adherence to the Mediterranean diet and nutritional status in Dalmatian kidney transplant recipients: a cross-sectional study

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