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Showing 1–3 of 3 results
Advanced filters: Author: Marijne Vermeer Clear advanced filters

  • IL-23 promotes tumor growth in preclinical cancer models and correlates with adverse clinical outcomes. Here, Becher and colleagues find that IL-23 produced by tumor-associated macrophages stabilizes Treg cell identity, promoting immunosuppression and tumor growth.

    • Tobias Wertheimer
    • Pascale Zwicky
    • Burkhard Becher
    ResearchOpen Access
    Nature Immunology
    Volume: 25, P: 512-524

  • Dormancy of disseminated cancer cells has been described in patients with breast cancer and associated with late metastatic relapses. Here the authors show that CD39+PD-1+CD8+ T cells correlate with increased disease free survival post-resection in breast cancer patients, and promote dormancy in a preclinical model.

    • Paulino Tallón de Lara
    • Héctor Castañón
    • Maries van den Broek
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-14