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Showing 1–5 of 5 results

Advanced filters: Author: Marin L. Gantner Clear advanced filters

Serine biosynthesis defect due to haploinsufficiency of PHGDH causes retinal disease

Rare variants in the gene encoding PHGDH, the rate-limiting enzyme in de novo serine biosynthesis, are identified as responsible for serine deficiency associated with the macular degenerative disease MacTel.

Kevin Eade
Marin L. Gantner
Rando Allikmets
Research22 Mar 2021
Nature Metabolism

Volume: 3, P: 366-377
Correction: Corrigendum: Retinal lipid and glucose metabolism dictates angiogenesis through the lipid sensor Ffar1

Jean-Sébastien Joyal
Ye Sun
Lois E H Smith
Amendments and Corrections07 Jun 2016
Nature Medicine

Volume: 22, P: 692
Insulin-regulated serine and lipid metabolism drive peripheral neuropathy

Serine deficiency can increase small fibre neuropathy in wild-type mice and serine replacement in diabetic mice alleviates diabetic neuropathy, directly linking amino acid metabolism to peripheral nerve disorders.

Michal K. Handzlik
Jivani M. Gengatharan
Christian M. Metallo
ResearchOpen Access25 Jan 2023
Nature

Volume: 614, P: 118-124
Retinal lipid and glucose metabolism dictates angiogenesis through the lipid sensor Ffar1

Retinal neovascularization, as occurs in age-related macular degeneration, may result from an increase in VEGFA levels due to dysregulated lipid and glucose metabolism within photoreceptors.

Jean-Sébastien Joyal
Ye Sun
Lois E H Smith
Research14 Mar 2016
Nature Medicine

Volume: 22, P: 439-445
The Signaling Pathways Project, an integrated ‘omics knowledgebase for mammalian cellular signaling pathways

Scott A. Ochsner
David Abraham
Neil J. McKenna
ResearchOpen Access31 Oct 2019
Scientific Data

Volume: 6, P: 1-21