The oncogenic splicing factor TRA2β is reported to be upregulated in human cancers partly by increased TRA2β poison exon (PE) skipping. Here the authors show that forced inclusion of this PE using antisense oligonucleotides depletes TRA2β protein levels and generates long non-coding RNAs that sequester nuclear proteins, leading to cancer toxicity.
- Nathan K. Leclair
- Mattia Brugiolo
- Olga Anczuków
