Nature Search

Characterising acute and chronic care needs: insights from the Global Burden of Disease Study 2019

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Cecilia Anza-Ramirez
J. Jaime Miranda
Yves Miel H. Zuniga
ResearchOpen Access07 May 2025
Nature Communications

Volume: 16, P: 1-36
Long-term diazepam treatment enhances microglial spine engulfment and impairs cognitive performance via the mitochondrial 18 kDa translocator protein (TSPO)

Benzodiazepines, used to treat anxiety and sleep disorders, may cause cognitive impairment. Shi et al. demonstrate that this is caused by interaction with the mitochondrial protein TSPO, which drives microglia to excessively remove synapses.

Yuan Shi
Mochen Cui
Mario M. Dorostkar
Research28 Feb 2022
Nature Neuroscience

Volume: 25, P: 317-329
Anemia prevalence in women of reproductive age in low- and middle-income countries between 2000 and 2018

Geospatial estimates of the prevalence of anemia in women of reproductive age across 82 low-income and middle-income countries reveals considerable heterogeneity and inequality at national and subnational levels, with few countries on track to meet the WHO Global Nutrition Targets by 2030.

Damaris Kinyoki
Aaron E. Osgood-Zimmerman
Simon I. Hay
ResearchOpen Access12 Oct 2021
Nature Medicine

Volume: 27, P: 1761-1782
Mapping local patterns of childhood overweight and wasting in low- and middle-income countries between 2000 and 2017

Fine-scale geospatial mapping of overweight and wasting (two components of the double burden of malnutrition) in 105 LMICs shows that overweight has increased from 5.2% in 2000 to 6.0% in children under 5 in 2017. Although overall wasting decreased over the same period, most countries are not on track to meet the World Health Organization’s Global Nutrition Target of <5% in over half of LMICs by 2025.

Damaris K. Kinyoki
Jennifer M. Ross
Simon I. Hay
ResearchOpen Access20 Apr 2020
Nature Medicine

Volume: 26, P: 750-759
Multiomic profiling of medulloblastoma reveals subtype-specific targetable alterations at the proteome and N-glycan level

Medulloblastomas (MBs) are highly heterogeneous paediatric brain tumours that remain challenging to treat. Here, the authors integrate proteomics, epigenomics, transcriptomics and post-translational modification analyses to find molecular subgroups and potential therapeutic targets in MB tumours.

Shweta Godbole
Hannah Voß
Julia E. Neumann
ResearchOpen Access24 Jul 2024
Nature Communications

Volume: 15, P: 1-24
Mapping routine measles vaccination in low- and middle-income countries

Although progress in the coverage of routine measles vaccination in children in low- and middle-income countries was made during 2000–2019, many countries remain far from the goal of 80% coverage in all districts by 2019.

Alyssa N. Sbarra
Sam Rolfe
Jonathan F. Mosser
ResearchOpen Access16 Dec 2020
Nature

Volume: 589, P: 415-419
A genetically encoded reporter of synaptic activity in vivo

Fusion of the genetically-encoded calcium indicator GCaMP2 to synaptophysin localizes the sensor to neuron presynaptic terminals and conveys linear responsiveness over a wider range of spike frequencies. The sensor allowed measurement of synaptic activity caused by spiking as well as graded voltage signals during in vivo imaging in zebrafish.

Elena Dreosti
Benjamin Odermatt
Leon Lagnado
Research08 Nov 2009
Nature Methods

Volume: 6, P: 883-889
Pathological α-synuclein impairs adult-born granule cell development and functional integration in the olfactory bulb

Aggregation-prone forms of α-synuclein lead to degeneration of midbrain dopaminergic neurons, as seen in Parkinson’s disease, but less is known about the effects that the noxious protein has in other brain regions. Here, the authors investigate the effect of a pathological form of α-synuclein on the functional integration of new neurons into the olfactory bulb of adult mice.

Johanna Neuner
Saak V. Ovsepian
Jochen Herms
ResearchOpen Access28 May 2014
Nature Communications

Volume: 5, P: 1-12
A mouse model for embryonal tumors with multilayered rosettes uncovers the therapeutic potential of Sonic-hedgehog inhibitors

Simultaneous activation of Wnt and Shh pathways in murine neural precursor cells results in the formation of embryonal tumors with multilayered rosettes (ETMR) that recapitulate the histological and molecular features of human tumors. This novel mouse model represents a platform for evaluating therapeutic approaches for this rare malignant pediatric brain tumor, and provides novel insights into the cell of origin and molecular mechanisms driving the disease.

Julia E Neumann
Annika K Wefers
Ulrich Schüller
Research11 Sept 2017
Nature Medicine

Volume: 23, P: 1191-1202
Arc illuminates Alzheimer's pathophysiology

Pathological alterations in Alzheimer's disease disrupt neuronal network function. An in vivo imaging study using a fluorescent reporter of neuronal activity finds dysfunction specifically in those neurons near amyloid plaques.

Mario M Dorostkar
Jochen Herms
News & Views25 Sept 2012
Nature Neuroscience

Volume: 15, P: 1323-1325
Extent and prognostic value of MGMT promotor methylation in glioma WHO grade II

Philipp Karschnia
Nico Teske
Niklas Thon
ResearchOpen Access12 Nov 2020
Scientific Reports

Volume: 10, P: 1-9
Subventricular zone involvement is associated with worse outcome in glioma WHO grade 2 depending on molecular markers

Philipp Karschnia
Jonathan Weller
Niklas Thon
ResearchOpen Access08 Oct 2021
Scientific Reports

Volume: 11, P: 1-10
Author Correction: Mapping local patterns of childhood overweight and wasting in low- and middle-income countries between 2000 and 2017

Damaris K. Kinyoki
Jennifer M. Ross
Simon I. Hay
Amendments and CorrectionsOpen Access02 Jul 2020
Nature Medicine

Volume: 26, P: 1308
Translocator protein (18kDa) TSPO: a new diagnostic or therapeutic target for stress-related disorders?

Rainer Rupprecht
Christian H. Wetzel
Inga D. Neumann
Reviews20 Apr 2022
Molecular Psychiatry

Volume: 27, P: 2918-2926

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Characterising acute and chronic care needs: insights from the Global Burden of Disease Study 2019

Long-term diazepam treatment enhances microglial spine engulfment and impairs cognitive performance via the mitochondrial 18 kDa translocator protein (TSPO)

Anemia prevalence in women of reproductive age in low- and middle-income countries between 2000 and 2018

Mapping local patterns of childhood overweight and wasting in low- and middle-income countries between 2000 and 2017

Multiomic profiling of medulloblastoma reveals subtype-specific targetable alterations at the proteome and N-glycan level

Mapping routine measles vaccination in low- and middle-income countries

A genetically encoded reporter of synaptic activity in vivo

Pathological α-synuclein impairs adult-born granule cell development and functional integration in the olfactory bulb

A mouse model for embryonal tumors with multilayered rosettes uncovers the therapeutic potential of Sonic-hedgehog inhibitors

Arc illuminates Alzheimer's pathophysiology

Extent and prognostic value of MGMT promotor methylation in glioma WHO grade II

Subventricular zone involvement is associated with worse outcome in glioma WHO grade 2 depending on molecular markers

Author Correction: Mapping local patterns of childhood overweight and wasting in low- and middle-income countries between 2000 and 2017

Translocator protein (18kDa) TSPO: a new diagnostic or therapeutic target for stress-related disorders?

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