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Scientific Reports (3)
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Showing 1–5 of 5 results

Advanced filters: Author: Mario Kuttke Clear advanced filters

The PI3K pathway preserves metabolic health through MARCO-dependent lipid uptake by adipose tissue macrophages

The PI3K–PTEN signalling pathway is a central regulator of metabolic homeostasis. Brunner et al. find that cell-intrinsic PI3K signalling allows adipose tissue macrophages to buffer obesity-induced lipotoxicity by promoting lipid uptake and catabolism.

Julia S. Brunner
Andrea Vogel
Gernot Schabbauer
Research16 Nov 2020
Nature Metabolism

Volume: 2, P: 1427-1442
Acquired resistance to anti-MAPK targeted therapy confers an immune-evasive tumor microenvironment and cross-resistance to immunotherapy in melanoma

Obenauf and colleagues report that acquired resistance to BRAF and MEK inhibitors in melanoma confers cross-resistance to immune checkpoint blockade by fostering a cancer cell–instructed, immune-evasive tumor microenvironment.

Lisa Haas
Anais Elewaut
Anna C. Obenauf
Research15 Jul 2021
Nature Cancer

Volume: 2, P: 693-708
Erratum: Sustained PI3K Activation exacerbates BLM-induced Lung Fibrosis via activation of pro-inflammatory and pro-fibrotic pathways

Julia Barbara Kral
Mario Kuttke
Gernot Schabbauer
Amendments and CorrectionsOpen Access20 May 2016
Scientific Reports

Volume: 6, P: 1
Loss of MAPK-activated protein kinase 2 enables potent dendritic cell-driven anti-tumour T cell response

Klara Soukup
Angela Halfmann
Alexander M. Dohnal
ResearchOpen Access18 Sept 2017
Scientific Reports

Volume: 7, P: 1-15
Sustained PI3K Activation exacerbates BLM-induced Lung Fibrosis via activation of pro-inflammatory and pro-fibrotic pathways

Julia Barbara Kral
Mario Kuttke
Gernot Schabbauer
ResearchOpen Access14 Mar 2016
Scientific Reports

Volume: 6, P: 1-17