Nature Search

New insights into the genetic etiology of Alzheimer’s disease and related dementias

Meta-analysis of genome-wide association studies on Alzheimer’s disease and related dementias identifies new loci and enables generation of a new genetic risk score associated with the risk of future Alzheimer’s disease and dementia.

Céline Bellenguez
Fahri Küçükali
Jean-Charles Lambert
ResearchOpen Access04 Apr 2022
Nature Genetics

Volume: 54, P: 412-436
Diminishing benefits of urban living for children and adolescents’ growth and development

The advantage of living in cities compared with rural areas with respect to height and BMI in children and adolescents has generally become smaller globally from 1990 to 2020, except in sub-Saharan Africa.

Anu Mishra
Bin Zhou
Majid Ezzati
ResearchOpen Access29 Mar 2023
Nature

Volume: 615, P: 874-883
Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology

A cross-ancestry genome-wide association meta-analysis of amyotrophic lateral sclerosis (ALS) including 29,612 patients with ALS and 122,656 controls identifies 15 risk loci with distinct genetic architectures and neuron-specific biology.

Wouter van Rheenen
Rick A. A. van der Spek
Jan H. Veldink
ResearchOpen Access06 Dec 2021
Nature Genetics

Volume: 53, P: 1636-1648
The Akt/mTOR and MNK/eIF4E pathways rewire the prostate cancer translatome to secrete HGF, SPP1 and BGN and recruit suppressive myeloid cells

Alimonti and colleagues show that coordinated activation of the Akt/mTOR and MNK/eIF4E pathways rewires the prostate cancer translatome to secrete HGF, SPP1 and BGN and recruit suppressive myeloid cells, which can be therapeutically targeted.

Daniela Brina
Adele Ponzoni
Andrea Alimonti
Research17 Jul 2023
Nature Cancer

Volume: 4, P: 1102-1121
Id proteins synchronize stemness and anchorage to the niche of neural stem cells

Iavarone, Lasorella and colleagues develop genetic mouse models to study the roles of inhibitor of DNA-binding (Id) proteins in neural stem-cell maintenance. They show that Id proteins promote neural stem-cell adhesion to their niche by driving the transcriptional repression of Rap1GAP, thereby maintaining the activity of the Rap1 GTPase, a known regulator of integrin adhesion.

Francesco Niola
Xudong Zhao
Anna Lasorella
Research22 Apr 2012
Nature Cell Biology

Volume: 14, P: 477-487
Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores

Known genetic loci account for only a fraction of the genetic contribution to Alzheimer’s disease. Here, the authors have performed a large genome-wide meta-analysis comprising 409,435 individuals to discover 6 new loci and demonstrate the efficacy of an Alzheimer’s disease polygenic risk score.

Itziar de Rojas
Sonia Moreno-Grau
Agustín Ruiz
ResearchOpen Access07 Jun 2021
Nature Communications

Volume: 12, P: 1-16
Global landscape and genetic regulation of RNA editing in cortical samples from individuals with schizophrenia

Breen et al. map RNA editing profiles in cortical samples from individuals with schizophrenia and controls, and find links between altered RNA editing in glutamatergic and postsynaptic density genes and schizophrenia genetic risk architecture.

Michael S. Breen
Amanda Dobbyn
Elizabeth Zharovsky
Research27 Aug 2019
Nature Neuroscience

Volume: 22, P: 1402-1412
Rising rural body-mass index is the main driver of the global obesity epidemic in adults

Contrary to the view that urbanization is a major driver of the global rise in obesity, the global increase in body-mass index is shown to be mostly due to increases in the body-mass indexes of rural populations.

Honor Bixby
James Bentham
Majid Ezzati
ResearchOpen Access08 May 2019
Nature

Volume: 569, P: 260-264
Investigating the mechanisms underlying resistance to chemotherapy and to CRISPR-Cas9 in cancer cell lines

Francesca Tomasi
Matteo Pozzi
Mario Lauria
ResearchOpen Access05 Mar 2024
Scientific Reports

Volume: 14, P: 1-16
Functional annotation of rare structural variation in the human brain

Structural variants (SVs) contribute to the genetic architecture of many brain-related disorders. Here, the authors integrate SV calls from genome sequencing (n = 755) with RNA-seq data (n = 629) from post-mortem dorsal lateral prefrontal cortex to annotate the gene regulatory effects of SVs in the human brain and their potential to contribute to disease.

Lide Han
Xuefang Zhao
Douglas M. Ruderfer
ResearchOpen Access12 Jun 2020
Nature Communications

Volume: 11, P: 1-13
Consensus Clustering of temporal profiles for the identification of metabolic markers of pre-diabetes in childhood (EarlyBird 73)

Mario Lauria
Maria Persico
François-Pierre Martin
ResearchOpen Access23 Jan 2018
Scientific Reports

Volume: 8, P: 1-16
Author Correction: Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology

Wouter van Rheenen
Rick A. A. van der Spek
Jan H. Veldink
Amendments and CorrectionsOpen Access31 Jan 2022
Nature Genetics

Volume: 54, P: 361
Cross-disease analysis of Alzheimer’s disease and type-2 Diabetes highlights the role of autophagy in the pathophysiology of two highly comorbid diseases

Laura Caberlotto
T.-Phuong Nguyen
Lucia Carboni
ResearchOpen Access08 Mar 2019
Scientific Reports

Volume: 9, P: 1-13
Cross-species evidence from human and rat brain transcriptome for growth factor signaling pathway dysregulation in major depression

Lucia Carboni
Luca Marchetti
Aleksander A. Mathé
Research12 Jun 2018
Neuropsychopharmacology

Volume: 43, P: 2134-2145
Systems view of adipogenesis via novel omics-driven and tissue-specific activity scoring of network functional modules

Isar Nassiri
Rosario Lombardo
Corrado Priami
ResearchOpen Access07 Jul 2016
Scientific Reports

Volume: 6, P: 1-19
Integration of transcriptomic and genomic data suggests candidate mechanisms for APOE4-mediated pathogenic action in Alzheimer’s disease

Laura Caberlotto
Luca Marchetti
Silvia Parolo
ResearchOpen Access02 Sept 2016
Scientific Reports

Volume: 6, P: 1-10
Diversity of key players in the microbial ecosystems of the human body

Ferenc Jordán
Mario Lauria
Corrado Priami
ResearchOpen Access30 Oct 2015
Scientific Reports

Volume: 5, P: 1-10
Author Correction: Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores

Itziar de Rojas
Sonia Moreno-Grau
Agustín Ruiz
Amendments and CorrectionsOpen Access09 Feb 2023
Nature Communications

Volume: 14, P: 1-2
Large eQTL meta-analysis reveals differing patterns between cerebral cortical and cerebellar brain regions

Solveig K. Sieberts
Thanneer M. Perumal
Lara M. Mangravite
ResearchOpen Access12 Oct 2020
Scientific Data

Volume: 7, P: 1-11

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