Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–5 of 5 results
Advanced filters: Author: Mario Mauthe Clear advanced filters

  • Mauthe et al. find that protein aggregate clearance requires fragmentation of the aggregate by a chaperone module and a proteasomal regulatory particle for recruitment and clustering of selective autophagy receptors to initiate phagophore formation.

    • Mario Mauthe
    • Nicole van de Beek
    • Fulvio Reggiori
    ResearchOpen Access
    Nature Cell Biology
    Volume: 27, P: 1448-1464

  • During autophagy, AMPK and mTOR associate with ULK1 and regulate phosphatidylinositol 3-phosphate (PtdIns3P) production that mediates autophagosome formation via WIPI proteins. Here the authors show WIPI3 and WIPI4 have a scaffolding function upstream of PtdIns3P production and have a role in the PtdIns3P effector function of WIPI1-WIPI2 at nascent autophagosomes.

    • Daniela Bakula
    • Amelie J. Müller
    • Tassula Proikas-Cezanne
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-18

  • Coffer and colleagues report that the transcription factor FOXO3 regulates the induction of autophagy. In response to PI(3)K–Akt signalling, FOXO3 directly induces expression of glutamine synthase, which upregulates glutamine levels and triggers autophagy.

    • Kristan E. van der Vos
    • Pernilla Eliasson
    • Paul J. Coffer
    Research
    Nature Cell Biology
    Volume: 14, P: 829-837

  • The protein FAM134B is an endoplasmic reticulum (ER)-resident receptor that facilitates ER autophagy, and downregulation of this protein (mutations of which are also known to cause sensory neuropathy in humans) results in expanded ER structures and degeneration of mouse sensory neurons.

    • Aliaksandr Khaminets
    • Theresa Heinrich
    • Ivan Dikic
    Research
    Nature
    Volume: 522, P: 354-358